What compounds target NTRK2?

BiohacksAI has identified 42 compounds that interact with NTRK2 (neurotrophic receptor tyrosine kinase 2). Top compounds include: foretinib, tozasertib, ruxolitinib, ceritinib, nilotinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NTRK2 (neurotrophic receptor tyrosine)?

NTRK2 is neurotrophic receptor tyrosine kinase 2. It is a molecular target for 42 compounds documented in PubMed bioassay data. UniProt ID: Q16620. NCBI Gene ID: 4915.

NTRK2

MOLECULAR TARGET

neurotrophic receptor tyrosine kinase 2

UniProt: Q16620 NCBI Gene: 491542 compounds

NTRK2 (neurotrophic receptor tyrosine kinase 2) is targeted by 42 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NTRK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	foretinib	4.34	76
2	tozasertib	4.33	75
3	ruxolitinib	4.23	68
4	ceritinib	4.19	65
5	nilotinib	4.17	64
6	bosutinib	4.08	58
7	doramapimod	4.06	57
8	quizartinib	3.99	53
9	midostaurin	3.85	46
10	nintedanib	3.61	36
11	larotrectinib	3.50	32
12	tryptanthrin	3.47	31
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	bms 777607	3.37	28
16	linifanib	3.33	27
17	tandutinib	3.22	24
18	entrectinib	3.18	23
19	selitrectinib	3.14	22
20	78 dihydroxyflavone	3.14	22
21	dovitinib	3.09	21
22	lestaurtinib	3.04	20
23	repotrectinib	3.00	19
24	r 406	2.83	16
25	gw632580x	2.83	16
26	infigratinib	2.77	15
27	pha 665752	2.71	14
28	kw 2449	2.64	13
29	ast 487	2.56	12
30	defactinib	2.48	11
31	lorlatinib	2.48	11
32	bms 754807	2.30	9
33	su 014813	2.20	8
34	rebastinib	2.20	8
35	mk 2461	2.08	7
36	purvalanol b	2.08	7
37	sns 314 mesylate	1.95	6
38	Sorafenib	1.79	5
39	Crizotinib	1.39	3
40	tyrosol	1.39	3
41	sp600125	0.69	1
42	bdb chembl4574620	0.69	1

About NTRK2 as a Drug Target

NTRK2 (neurotrophic receptor tyrosine kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 42 compounds with documented NTRK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NTRK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.