NTRK3
MOLECULAR TARGETneurotrophic receptor tyrosine kinase 3
NTRK3 (neurotrophic receptor tyrosine kinase 3) is targeted by 33 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting NTRK3
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | foretinib | 4.34 | 76 |
| 2 | tozasertib | 4.33 | 75 |
| 3 | ruxolitinib | 4.23 | 68 |
| 4 | nilotinib | 4.17 | 64 |
| 5 | bosutinib | 4.08 | 58 |
| 6 | doramapimod | 4.06 | 57 |
| 7 | quizartinib | 3.99 | 53 |
| 8 | midostaurin | 3.85 | 46 |
| 9 | nintedanib | 3.61 | 36 |
| 10 | larotrectinib | 3.50 | 32 |
| 11 | pexidartinib | 3.43 | 30 |
| 12 | fedratinib | 3.40 | 29 |
| 13 | linifanib | 3.33 | 27 |
| 14 | tandutinib | 3.22 | 24 |
| 15 | entrectinib | 3.18 | 23 |
| 16 | selitrectinib | 3.14 | 22 |
| 17 | dovitinib | 3.09 | 21 |
| 18 | lestaurtinib | 3.04 | 20 |
| 19 | repotrectinib | 3.00 | 19 |
| 20 | r 406 | 2.83 | 16 |
| 21 | gw632580x | 2.83 | 16 |
| 22 | pha 665752 | 2.71 | 14 |
| 23 | kw 2449 | 2.64 | 13 |
| 24 | ast 487 | 2.56 | 12 |
| 25 | defactinib | 2.48 | 11 |
| 26 | lorlatinib | 2.48 | 11 |
| 27 | bms 754807 | 2.30 | 9 |
| 28 | su 014813 | 2.20 | 8 |
| 29 | rebastinib | 2.20 | 8 |
| 30 | Sorafenib | 1.79 | 5 |
| 31 | Crizotinib | 0.69 | 1 |
| 32 | sp600125 | 0.69 | 1 |
| 33 | bdb chembl4574620 | 0.69 | 1 |
About NTRK3 as a Drug Target
NTRK3 (neurotrophic receptor tyrosine kinase 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 33 compounds with documented NTRK3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
NTRK3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.