NUAK1
MOLECULAR TARGETNUAK family kinase 1
NUAK1 (NUAK family kinase 1) is targeted by 25 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting NUAK1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | tozasertib | 4.33 | 75 |
| 2 | bosutinib | 4.08 | 58 |
| 3 | midostaurin | 3.85 | 46 |
| 4 | brigatinib | 3.81 | 44 |
| 5 | neratinib | 3.66 | 38 |
| 6 | nintedanib | 3.61 | 36 |
| 7 | tae 684 | 3.43 | 30 |
| 8 | fedratinib | 3.40 | 29 |
| 9 | dovitinib | 3.09 | 21 |
| 10 | jnj 7706621 | 3.09 | 21 |
| 11 | lestaurtinib | 3.04 | 20 |
| 12 | ruboxistaurin | 2.94 | 18 |
| 13 | r 406 | 2.83 | 16 |
| 14 | pha 665752 | 2.71 | 14 |
| 15 | gsk 690693 | 2.64 | 13 |
| 16 | bx 795 | 2.40 | 10 |
| 17 | bms 754807 | 2.30 | 9 |
| 18 | su 014813 | 2.20 | 8 |
| 19 | prexasertib | 2.08 | 7 |
| 20 | maleimide | 1.95 | 6 |
| 21 | bastadin 7 | 1.95 | 6 |
| 22 | cerdulatinib | 1.95 | 6 |
| 23 | sra 737 | 1.95 | 6 |
| 24 | norlichexanthone | 1.79 | 5 |
| 25 | Quercetin | 0.69 | 1 |
About NUAK1 as a Drug Target
NUAK1 (NUAK family kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 25 compounds with documented NUAK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
NUAK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.