What compounds target NUCLEAR?

BiohacksAI has identified 162 compounds that interact with NUCLEAR (Nuclear factor erythroid 2-related factor 2 (human)). Top compounds include: alyssin [Supplementary Concept], Dimethyl Fumarate, Resveratrol, cycloheximide, Estrone. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NUCLEAR (Nuclear factor erythroid)?

NUCLEAR is Nuclear factor erythroid 2-related factor 2 (human). It is a molecular target for 162 compounds documented in PubMed bioassay data. UniProt ID: Q16236.

NUCLEAR

MOLECULAR TARGET

Nuclear factor erythroid 2-related factor 2 (human)

UniProt: Q16236162 compounds

NUCLEAR (Nuclear factor erythroid 2-related factor 2 (human)) is targeted by 162 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NUCLEAR

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	alyssin [Supplementary Concept]	3.18	23
2	Dimethyl Fumarate	2.40	10
3	Resveratrol	2.08	7
4	cycloheximide	1.95	6
5	Estrone	1.95	6
6	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	1.95	6
7	Methylene Blue	1.79	5
8	Methotrexate	1.79	5
9	Clotrimazole	1.79	5
10	dimethyl formamide	1.79	5
11	Dimethylformamide	1.79	5
12	Ethinyl Estradiol	1.79	5
13	Hydrocortisone	1.79	5
14	Niclosamide	1.79	5
15	Progesterone	1.61	4
16	Bromodeoxyuridine	1.61	4
17	Carboxin	1.61	4
18	Cladribine	1.61	4
19	Colchicine	1.61	4
20	Digoxin	1.61	4
21	Ethoxyquin Antioxidant; also	1.61	4
22	Fenofibrate	1.61	4
23	fluoranthene	1.61	4
24	Hexachlorophene	1.61	4
25	Cervugid [Supplementary Concept]	1.61	4
26	Leflunomide	1.61	4
27	Linuron	1.61	4
28	Mestranol	1.61	4
29	Phenoxybenzamine	1.61	4
30	Piperonyl Butoxide	1.61	4
31	vinblastine sulfate	1.61	4
32	Carbaryl	1.39	3
33	Corticosterone	1.39	3
34	Digitoxin	1.39	3
35	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	1.39	3
36	Disulfiram	1.39	3
37	Ethidium	1.39	3
38	Melphalan	1.39	3
39	Methoxsalen	1.39	3
40	Nisoldipine	1.39	3
41	Phenelzine	1.39	3
42	Reserpine	1.39	3
43	Rotenone	1.39	3
44	Triamcinolone	1.39	3
45	Vincamine	1.39	3
46	Melatonin	1.10	2
47	Prednisolone	1.10	2
48	2-Acetylaminofluorene	1.10	2
49	alsterpaullone	1.10	2
50	amlexanox	1.10	2

Showing top 50 of 162 compounds. Use the BiohacksAI search to explore all NUCLEAR modulators.

About NUCLEAR as a Drug Target

NUCLEAR (Nuclear factor erythroid 2-related factor 2 (human)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 162 compounds with documented NUCLEAR interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NUCLEAR inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.