What compounds target PAX8?

BiohacksAI has identified 26 compounds that interact with PAX8 (paired box 8). Top compounds include: Chlorhexidine, Demecolcine, Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide., Anisomycin, Colchicine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PAX8 (paired box 8)?

PAX8 is paired box 8. It is a molecular target for 26 compounds documented in PubMed bioassay data. UniProt ID: AAB34216. NCBI Gene ID: 7849.

PAX8

MOLECULAR TARGET

paired box 8

UniProt: AAB34216 NCBI Gene: 784926 compounds

PAX8 (paired box 8) is targeted by 26 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PAX8

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Chlorhexidine	1.95	6
2	Demecolcine	1.95	6
3	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	1.39	3
4	Anisomycin	1.10	2
5	Colchicine	1.10	2
6	colchine	1.10	2
7	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	1.10	2
8	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	1.10	2
9	Digoxin	1.10	2
10	Hexachlorophene	1.10	2
11	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	1.10	2
12	Podophyllotoxin	1.10	2
13	vinblastine sulfate	1.10	2
14	Vorinostat	1.10	2
15	2-Chloroadenosine 2-Chloroadenosine.	0.69	1
16	Astemizole Antihistamine drug now withdrawn from	0.69	1
17	Calcimycin	0.69	1
18	Ciclopirox	0.69	1
19	clofilium tosylate	0.69	1
20	Decitabine	0.69	1
21	Ethidium	0.69	1
22	gedunin	0.69	1
23	mg624	0.69	1
24	Nocodazole Nocodazole is	0.69	1
25	torin 1	0.69	1
26	tyrphostin 9	0.69	1

About PAX8 as a Drug Target

PAX8 (paired box 8) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 26 compounds with documented PAX8 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PAX8 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.