PDE4B
MOLECULAR TARGETphosphodiesterase 4B
PDE4B (phosphodiesterase 4B) is targeted by 22 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PDE4B
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | rolipram | 5.12 | 166 |
| 2 | sildenafil | 4.78 | 118 |
| 3 | roflumilast | 4.04 | 56 |
| 4 | isobutylmethylxanthine | 3.71 | 40 |
| 5 | cilomilast | 3.71 | 40 |
| 6 | piclamilast | 3.04 | 20 |
| 7 | apremilast | 2.89 | 17 |
| 8 | rolipram | 2.83 | 16 |
| 9 | zardaverine | 2.77 | 15 |
| 10 | crisaborole | 2.71 | 14 |
| 11 | cdp840 | 2.71 | 14 |
| 12 | moracin m | 2.56 | 12 |
| 13 | ro 201724 | 2.56 | 12 |
| 14 | ibudilast | 2.48 | 11 |
| 15 | moracin c | 2.40 | 10 |
| 16 | gsk778 | 2.08 | 7 |
| 17 | phthalazinone | 1.79 | 5 |
| 18 | arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from | 0.69 | 1 |
| 19 | Etazolate | 0.69 | 1 |
| 20 | Muscarine | 0.69 | 1 |
| 21 | Papaverine | 0.69 | 1 |
| 22 | bdb chembl4748750 | 0.69 | 1 |
About PDE4B as a Drug Target
PDE4B (phosphodiesterase 4B) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 22 compounds with documented PDE4B interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PDE4B inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.