PDPK1
MOLECULAR TARGET3-phosphoinositide dependent protein kinase 1
PDPK1 (3-phosphoinositide dependent protein kinase 1) is targeted by 18 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PDPK1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | midostaurin | 3.85 | 46 |
| 2 | nintedanib | 3.61 | 36 |
| 3 | jnj 7706621 | 3.09 | 21 |
| 4 | lestaurtinib | 3.04 | 20 |
| 5 | ruboxistaurin | 2.94 | 18 |
| 6 | r 406 | 2.83 | 16 |
| 7 | kw 2449 | 2.64 | 13 |
| 8 | quinazolinone | 2.64 | 13 |
| 9 | meridianin c | 2.56 | 12 |
| 10 | bx 795 | 2.40 | 10 |
| 11 | isoxanthohumol | 2.30 | 9 |
| 12 | 26 diaminopurine | 2.30 | 9 |
| 13 | su 014813 | 2.20 | 8 |
| 14 | meriolin 1 | 1.95 | 6 |
| 15 | bdb 5s 6r 7r 9r 16r 16 hydroxy 6 methoxy 5 methyl 7 methylamino 6 7 8 9 15 16 hexahy | 1.39 | 3 |
| 16 | sp600125 | 1.10 | 2 |
| 17 | alsterpaullone | 0.69 | 1 |
| 18 | kenpaullone | 0.69 | 1 |
About PDPK1 as a Drug Target
PDPK1 (3-phosphoinositide dependent protein kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 18 compounds with documented PDPK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PDPK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.