PLK1
MOLECULAR TARGETpolo like kinase 1
PLK1 (polo like kinase 1) is targeted by 13 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PLK1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | ly294002 | 1.61 | 4 |
| 2 | Wortmannin | 1.61 | 4 |
| 3 | myricetin-3-O-galactopyranoside [Supplementary Concept] | 0.69 | 1 |
| 4 | Oleic Acid | 0.69 | 1 |
| 5 | Quercetin | 0.69 | 1 |
| 6 | Simvastatin | 0.69 | 1 |
| 7 | cefaclor | 0.69 | 1 |
| 8 | Disulfiram | 0.69 | 1 |
| 9 | Hexachlorophene | 0.69 | 1 |
| 10 | Lithocholic Acid | 0.69 | 1 |
| 11 | Nisoldipine | 0.69 | 1 |
| 12 | Oxyphenbutazone | 0.69 | 1 |
| 13 | Oxytetracycline | 0.69 | 1 |
About PLK1 as a Drug Target
PLK1 (polo like kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 13 compounds with documented PLK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PLK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.