What compounds target POLB?

BiohacksAI has identified 30 compounds that interact with POLB (DNA polymerase beta). Top compounds include: Oleanolic Acid, stigmasterol, 4-Hydroxybenzoate-3-Monooxygenase, Ursolic Acid, Methyldopa. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is POLB (DNA polymerase beta)?

POLB is DNA polymerase beta. It is a molecular target for 30 compounds documented in PubMed bioassay data. UniProt ID: P06746. NCBI Gene ID: 5423.

POLB

MOLECULAR TARGET

DNA polymerase beta

UniProt: P06746 NCBI Gene: 542330 compounds

POLB (DNA polymerase beta) is targeted by 30 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting POLB

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Oleanolic Acid	1.95	6
2	stigmasterol	1.95	6
3	4-Hydroxybenzoate-3-Monooxygenase	1.61	4
4	Ursolic Acid	1.10	2
5	Methyldopa	1.10	2
6	DEAD-box RNA Helicases	0.69	1
7	Thioctic Acid	0.69	1
8	egcg	0.69	1
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
10	Methylene Blue	0.69	1
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
12	Quercetin	0.69	1
13	Rosmarinic Acid	0.69	1
14	Rutin	0.69	1
15	Methotrexate	0.69	1
16	Aurintricarboxylic Acid	0.69	1
17	calycosin	0.69	1
18	Demeclocycline	0.69	1
19	Dequalinium	0.69	1
20	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	0.69	1
21	Hexachlorophene	0.69	1
22	Idarubicin	0.69	1
23	Oxytetracycline	0.69	1
24	piceatannol	0.69	1
25	Nitroprusside	0.69	1
26	sp600125	0.69	1
27	Stavudine	0.69	1
28	streptonigrin	0.69	1
29	alphitonin [Supplementary Concept] from	0.69	1
30	Thioctic Acid	0.69	1

About POLB as a Drug Target

POLB (DNA polymerase beta) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 30 compounds with documented POLB interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

POLB inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.