POLH
MOLECULAR TARGETDNA polymerase eta
POLH (DNA polymerase eta) is targeted by 22 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting POLH
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | myricetin-3-O-galactopyranoside [Supplementary Concept] | 1.39 | 3 |
| 2 | Aurintricarboxylic Acid | 1.39 | 3 |
| 3 | alpha-Linolenic Acid | 1.10 | 2 |
| 4 | Cefixime | 1.10 | 2 |
| 5 | Diiodotyrosine | 1.10 | 2 |
| 6 | gamma-Linolenic Acid | 1.10 | 2 |
| 7 | Levodopa | 1.10 | 2 |
| 8 | Kaempferols | 0.69 | 1 |
| 9 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | 0.69 | 1 |
| 10 | Quercetin | 0.69 | 1 |
| 11 | ag490 | 0.69 | 1 |
| 12 | Methotrexate | 0.69 | 1 |
| 13 | Ampicillin Semi-synthetic derivative of penicillin that functions as | 0.69 | 1 |
| 14 | Cefotetan | 0.69 | 1 |
| 15 | Ethidium | 0.69 | 1 |
| 16 | Hexachlorophene | 0.69 | 1 |
| 17 | Idarubicin | 0.69 | 1 |
| 18 | Masoprocol | 0.69 | 1 |
| 19 | Norepinephrine Precursor of epinephrine that is secreted by | 0.69 | 1 |
| 20 | Oxytetracycline | 0.69 | 1 |
| 21 | piceatannol | 0.69 | 1 |
| 22 | streptonigrin | 0.69 | 1 |
About POLH as a Drug Target
POLH (DNA polymerase eta) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 22 compounds with documented POLH interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
POLH inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.