What compounds target POLI?

BiohacksAI has identified 27 compounds that interact with POLI (DNA polymerase iota). Top compounds include: myricetin-3-O-galactopyranoside [Supplementary Concept], Methyldopa, Quercetin, alpha-Linolenic Acid, Aurintricarboxylic Acid. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is POLI (DNA polymerase iota)?

POLI is DNA polymerase iota. It is a molecular target for 27 compounds documented in PubMed bioassay data. UniProt ID: Q9UNA4. NCBI Gene ID: 11201.

POLI

MOLECULAR TARGET

DNA polymerase iota

UniProt: Q9UNA4 NCBI Gene: 1120127 compounds

POLI (DNA polymerase iota) is targeted by 27 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting POLI

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	1.79	5
2	Methyldopa	1.39	3
3	Quercetin	1.10	2
4	alpha-Linolenic Acid	1.10	2
5	Aurintricarboxylic Acid	1.10	2
6	Cefixime	1.10	2
7	Diiodotyrosine	1.10	2
8	Ethidium	1.10	2
9	gamma-Linolenic Acid	1.10	2
10	Levodopa	1.10	2
11	Kaempferols	0.69	1
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
13	Methotrexate	0.69	1
14	Ampicillin Semi-synthetic derivative of penicillin that functions as	0.69	1
15	candesartan cilexetil [Supplementary Concept]	0.69	1
16	Carmine Coloring matter from	0.69	1
17	Cefotetan	0.69	1
18	Cisplatin	0.69	1
19	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	0.69	1
20	Catechin	0.69	1
21	Idarubicin	0.69	1
22	Masoprocol	0.69	1
23	Norepinephrine Precursor of epinephrine that is secreted by	0.69	1
24	piceatannol	0.69	1
25	streptonigrin	0.69	1
26	alphitonin [Supplementary Concept] from	0.69	1
27	Wortmannin	0.69	1

About POLI as a Drug Target

POLI (DNA polymerase iota) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 27 compounds with documented POLI interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

POLI inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.