What compounds target PPARG?

BiohacksAI has identified 83 compounds that interact with PPARG (peroxisome proliferator activated receptor gamma). Top compounds include: Pioglitazone, Troglitazone, Methylene Blue, Thyroxine, Thyroxine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PPARG (peroxisome proliferator activated)?

PPARG is peroxisome proliferator activated receptor gamma. It is a molecular target for 83 compounds documented in PubMed bioassay data. UniProt ID: BAH02283. NCBI Gene ID: 5468.

PPARG

MOLECULAR TARGET

peroxisome proliferator activated receptor gamma

UniProt: BAH02283 NCBI Gene: 546883 compounds

PPARG (peroxisome proliferator activated receptor gamma) is targeted by 83 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PPARG

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Pioglitazone	4.51	90
2	Troglitazone	3.91	49
3	Methylene Blue	2.64	13
4	Thyroxine	2.30	9
5	Thyroxine	2.30	9
6	Indomethacin	1.95	6
7	Genistein	1.79	5
8	Warfarin	1.79	5
9	Glyburide	1.79	5
10	Rotenone	1.79	5
11	urolithin b	1.79	5
12	alpha-Linolenic Acid	1.61	4
13	Bezafibrate	1.61	4
14	Linoleic Acid	1.61	4
15	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.61	4
16	sulindac sulfide	1.61	4
17	Triiodothyronine	1.61	4
18	Apigenin 5,7,4'-trihydroxy-flavone,	1.39	3
19	chrysin	1.39	3
20	Kaempferols	1.39	3
21	Resveratrol	1.39	3
22	candesartan cilexetil [Supplementary Concept]	1.39	3
23	Ethoxyquin Antioxidant; also	1.39	3
24	Glutaral	1.39	3
25	Loratadine	1.39	3
26	Losartan	1.10	2
27	Mepentol [Supplementary Concept]	1.10	2
28	Dinitrochlorobenzene	1.10	2
29	Disulfiram	1.10	2
30	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	1.10	2
31	Ethidium	1.10	2
32	Fenofibrate	1.10	2
33	Feprazone	1.10	2
34	lonidamine	1.10	2
35	Maprotiline	1.10	2
36	Niflumic Acid	1.10	2
37	o-Phthalaldehyde	1.10	2
38	Oxaprozin	1.10	2
39	Prostaglandin D2	1.10	2
40	Spironolactone	1.10	2
41	Thioridazine	1.10	2
42	trequinsin hydrochloride	1.10	2
43	trichostatic acid [Supplementary Concept] related to trichostatin	1.10	2
44	Arachidonic Acid	0.69	1
45	Dehydroepiandrosterone Sulfate	0.69	1
46	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
47	Oleic Acid	0.69	1
48	Quercetin	0.69	1
49	Rutin	0.69	1
50	Vitamin	0.69	1

Showing top 50 of 83 compounds. Use the BiohacksAI search to explore all PPARG modulators.

About PPARG as a Drug Target

PPARG (peroxisome proliferator activated receptor gamma) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 83 compounds with documented PPARG interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PPARG inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.