What compounds target PTGS1?

BiohacksAI has identified 77 compounds that interact with PTGS1 (prostaglandin-endoperoxide synthase 1). Top compounds include: Indomethacin, Celecoxib, Naproxen, sc560, Resveratrol. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PTGS1 (prostaglandin-endoperoxide synthase 1)?

PTGS1 is prostaglandin-endoperoxide synthase 1. It is a molecular target for 77 compounds documented in PubMed bioassay data. UniProt ID: Q63921. NCBI Gene ID: 24693.

PTGS1

MOLECULAR TARGET

prostaglandin-endoperoxide synthase 1

UniProt: Q63921 NCBI Gene: 2469377 compounds

PTGS1 (prostaglandin-endoperoxide synthase 1) is targeted by 77 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PTGS1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Indomethacin	4.37	78
2	Celecoxib	3.85	46
3	Naproxen	2.40	10
4	sc560	2.30	9
5	Resveratrol	1.61	4
6	Meloxicam	1.61	4
7	ns398	1.61	4
8	Etodolac	1.39	3
9	Oxaprozin	1.39	3
10	Tolmetin	1.39	3
11	Glutathione	1.10	2
12	Oleic Acid	1.10	2
13	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	1.10	2
14	Simvastatin	1.10	2
15	Ascorbic Acid	1.10	2
16	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	1.10	2
17	alpha-Linolenic Acid	1.10	2
18	Ascorbic Acid	1.10	2
19	beta Carotene	1.10	2
20	Bromocriptine	1.10	2
21	Carbaryl	1.10	2
22	Caspofungin	1.10	2
23	Dexrazoxane	1.10	2
24	Hexachlorophene	1.10	2
25	Levodopa	1.10	2
26	Nialamide	1.10	2
27	Penicillamine 3-Mercapto-D-valine.	1.10	2
28	Phenelzine	1.10	2
29	Phenylbutazone	1.10	2
30	Prenalterol	1.10	2
31	Pyridoxal Phosphate This is	1.10	2
32	cbd	0.69	1
33	Minocycline	0.69	1
34	pterostilbene	0.69	1
35	Ursolic Acid	0.69	1
36	Vitamin K 2	0.69	1
37	Acetylcysteine	0.69	1
38	Anthralin	0.69	1
39	butein	0.69	1
40	Calcitriol	0.69	1
41	cannabidiol	0.69	1
42	Cephacetrile	0.69	1
43	Cephaloglycin	0.69	1
44	Crizotinib	0.69	1
45	Deamino Arginine Vasopressin	0.69	1
46	Dequalinium	0.69	1
47	Epirubicin	0.69	1
48	Physostigmine	0.69	1
49	Ezetimibe	0.69	1
50	Felypressin	0.69	1

Showing top 50 of 77 compounds. Use the BiohacksAI search to explore all PTGS1 modulators.

About PTGS1 as a Drug Target

PTGS1 (prostaglandin-endoperoxide synthase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 77 compounds with documented PTGS1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PTGS1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.