What compounds target PTK2B?

BiohacksAI has identified 44 compounds that interact with PTK2B (protein tyrosine kinase 2 beta). Top compounds include: alvocidib, foretinib, tozasertib, ponatinib, ceritinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PTK2B (protein tyrosine kinase)?

PTK2B is protein tyrosine kinase 2 beta. It is a molecular target for 44 compounds documented in PubMed bioassay data. UniProt ID: Q14289. NCBI Gene ID: 2185.

PTK2B

MOLECULAR TARGET

protein tyrosine kinase 2 beta

UniProt: Q14289 NCBI Gene: 218544 compounds

PTK2B (protein tyrosine kinase 2 beta) is targeted by 44 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PTK2B

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	alvocidib	4.52	91
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	ponatinib	4.26	70
5	ceritinib	4.19	65
6	bosutinib	4.08	58
7	doramapimod	4.06	57
8	bi 2536	4.01	54
9	midostaurin	3.85	46
10	brigatinib	3.81	44
11	neratinib	3.66	38
12	nintedanib	3.61	36
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	gilteritinib	3.40	29
16	mln 8054	3.33	27
17	lestaurtinib	3.04	20
18	pf 03758309	3.00	19
19	danusertib	2.94	18
20	r 406	2.83	16
21	k 252a	2.83	16
22	pf 00562271	2.77	15
23	hesperadin	2.77	15
24	pha 665752	2.71	14
25	kw 2449	2.64	13
26	ast 487	2.56	12
27	defactinib	2.48	11
28	mk 5108	2.48	11
29	lorlatinib	2.48	11
30	azd 7762	2.30	9
31	bms 754807	2.30	9
32	azd 1480	2.30	9
33	tyrphostin 23	2.30	9
34	su 014813	2.20	8
35	rebastinib	2.20	8
36	golvatinib	2.20	8
37	cyc 116	2.08	7
38	asp 3026	2.08	7
39	pf 03814735	1.79	5
40	ucn 01	1.79	5
41	Crizotinib	0.69	1
42	cycloheximide	0.69	1
43	Pioglitazone	0.69	1
44	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	0.69	1

About PTK2B as a Drug Target

PTK2B (protein tyrosine kinase 2 beta) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 44 compounds with documented PTK2B interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PTK2B inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.