Question 1

What compounds target RAPGEF3?

Accepted Answer

BiohacksAI has identified 25 compounds that interact with RAPGEF3 (Rap guanine nucleotide exchange factor 3). Top compounds include: Luteolin 5,7,3',4'-tetrahydroxy-flavone,, Cyclic AMP, Cyclic AMP, Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables., Trapidil. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is RAPGEF3 (Rap guanine nucleotide)?

Accepted Answer

RAPGEF3 is Rap guanine nucleotide exchange factor 3. It is a molecular target for 25 compounds documented in PubMed bioassay data. UniProt ID: O95398. NCBI Gene ID: 10411.

#	Compound	Confidence	Active Assays
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	2.48	11
2	Cyclic AMP	2.30	9
3	Cyclic AMP	2.30	9
4	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	2.20	8
5	Trapidil	2.20	8
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	1.79	5
7	rafoxanide	1.79	5
8	Arachidonic Acid	1.61	4
9	Aurintricarboxylic Acid	1.61	4
10	Dihydroxyphenylalanine	1.61	4
11	Evans Blue	1.61	4
12	Idarubicin	1.61	4
13	Hexachlorophene	1.39	3
14	Night Vision Function of	1.10	2
15	Quercetin	1.10	2
16	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	1.10	2
17	Bromocriptine	1.10	2
18	candesartan cilexetil [Supplementary Concept]	1.10	2
19	cardamonin	1.10	2
20	Daunorubicin	1.10	2
21	Catechin	1.10	2
22	Ethynodiol Diacetate	1.10	2
23	Masoprocol	1.10	2
24	Tocainide	1.10	2
25	Troglitazone	1.10	2

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RAPGEF3

Compounds Targeting RAPGEF3

About RAPGEF3 as a Drug Target