What compounds target RARA?

BiohacksAI has identified 135 compounds that interact with RARA (retinoic acid receptor alpha). Top compounds include: Disulfiram, Progesterone, cycloheximide, Adapalene, Hexachlorophene. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is RARA (retinoic acid receptor)?

RARA is retinoic acid receptor alpha. It is a molecular target for 135 compounds documented in PubMed bioassay data. UniProt ID: P10276. NCBI Gene ID: 5914.

RARA

MOLECULAR TARGET

retinoic acid receptor alpha

UniProt: P10276 NCBI Gene: 5914135 compounds

RARA (retinoic acid receptor alpha) is targeted by 135 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting RARA

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Disulfiram	2.08	7
2	Progesterone	1.95	6
3	cycloheximide	1.95	6
4	Adapalene	1.79	5
5	Hexachlorophene	1.79	5
6	Astemizole Antihistamine drug now withdrawn from	1.61	4
7	Azacitidine	1.61	4
8	Azacitidine	1.61	4
9	Celecoxib	1.61	4
10	Dactinomycin	1.61	4
11	Danazol	1.61	4
12	Dinitrochlorobenzene	1.61	4
13	Ethidium	1.61	4
14	Norethindrone	1.61	4
15	Oxymetholone	1.61	4
16	Promethazine	1.61	4
17	Budesonide	1.39	3
18	Genistein	1.39	3
19	Vitamin	1.39	3
20	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.39	3
21	Chlorhexidine	1.39	3
22	Clotrimazole	1.39	3
23	Desoxycorticosterone	1.39	3
24	Levonorgestrel	1.39	3
25	Nisoldipine	1.39	3
26	Norgestrel	1.39	3
27	Rotenone	1.39	3
28	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	1.39	3
29	Troglitazone	1.39	3
30	Pueraria	1.10	2
31	Methylene Blue	1.10	2
32	Resveratrol	1.10	2
33	Testosterone	1.10	2
34	Aprepitant	1.10	2
35	Betamethasone Valerate	1.10	2
36	candesartan cilexetil [Supplementary Concept]	1.10	2
37	Chlormadinone Acetate	1.10	2
38	Colchicine	1.10	2
39	Dasatinib	1.10	2
40	Daunorubicin	1.10	2
41	dilazep	1.10	2
42	Dimethisterone	1.10	2
43	Emetine	1.10	2
44	Estriol	1.10	2
45	Estrone	1.10	2
46	Ethoxyquin Antioxidant; also	1.10	2
47	Fluspirilene	1.10	2
48	Flutamide	1.10	2
49	Gemfibrozil	1.10	2
50	Gestrinone	1.10	2

Showing top 50 of 135 compounds. Use the BiohacksAI search to explore all RARA modulators.

About RARA as a Drug Target

RARA (retinoic acid receptor alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 135 compounds with documented RARA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

RARA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.