What compounds target RORC?

BiohacksAI has identified 183 compounds that interact with RORC (RAR-related orphan receptor gamma). Top compounds include: Digoxin, Disulfiram, Ursolic Acid, cycloheximide, Hexachlorophene. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is RORC (RAR-related orphan receptor)?

RORC is RAR-related orphan receptor gamma. It is a molecular target for 183 compounds documented in PubMed bioassay data. UniProt ID: P51450. NCBI Gene ID: 19885.

RORC

MOLECULAR TARGET

RAR-related orphan receptor gamma

UniProt: P51450 NCBI Gene: 19885183 compounds

RORC (RAR-related orphan receptor gamma) is targeted by 183 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting RORC

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Digoxin	3.00	19
2	Disulfiram	2.77	15
3	Ursolic Acid	2.30	9
4	cycloheximide	2.30	9
5	Hexachlorophene	2.30	9
6	Colchicine	2.08	7
7	Dactinomycin	2.08	7
8	Progesterone	1.95	6
9	Flutamide	1.95	6
10	Niclosamide	1.95	6
11	Dehydroepiandrosterone	1.79	5
12	Resveratrol	1.79	5
13	Chlorhexidine	1.79	5
14	Ciclopirox	1.79	5
15	Clotrimazole	1.79	5
16	Dehydroepiandrosterone	1.79	5
17	Digitoxin	1.79	5
18	Dihydrotestosterone	1.79	5
19	Lovastatin	1.79	5
20	Methyltestosterone	1.79	5
21	Rotenone	1.79	5
22	Troglitazone	1.79	5
23	Budesonide	1.61	4
24	Androstenedione	1.61	4
25	Astemizole Antihistamine drug now withdrawn from	1.61	4
26	Azacitidine	1.61	4
27	Azacitidine	1.61	4
28	Danazol	1.61	4
29	Daunorubicin	1.61	4
30	Dinitrochlorobenzene	1.61	4
31	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	1.61	4
32	Fluorometholone	1.61	4
33	Loratadine	1.61	4
34	Medroxyprogesterone Acetate	1.61	4
35	Vitamin K 3	1.61	4
36	Nitrofurantoin	1.61	4
37	Promethazine	1.61	4
38	vinblastine sulfate	1.61	4
39	plumbagin [Supplementary Concept]	1.39	3
40	Simvastatin	1.39	3
41	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.39	3
42	amlexanox	1.39	3
43	Estrone	1.39	3
44	Ethinyl Estradiol	1.39	3
45	Fluspirilene	1.39	3
46	Fusaric Acid	1.39	3
47	Idazoxan	1.39	3
48	Melphalan	1.39	3
49	Norethindrone	1.39	3
50	Oxyphenbutazone	1.39	3

Showing top 50 of 183 compounds. Use the BiohacksAI search to explore all RORC modulators.

About RORC as a Drug Target

RORC (RAR-related orphan receptor gamma) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 183 compounds with documented RORC interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

RORC inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.