What compounds target RPS6KB1?

BiohacksAI has identified 30 compounds that interact with RPS6KB1 (ribosomal protein S6 kinase B1). Top compounds include: alvocidib, foretinib, vandetanib, bosutinib, midostaurin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is RPS6KB1 (ribosomal protein S6)?

RPS6KB1 is ribosomal protein S6 kinase B1. It is a molecular target for 30 compounds documented in PubMed bioassay data. NCBI Gene ID: 6198.

RPS6KB1

MOLECULAR TARGET

ribosomal protein S6 kinase B1

NCBI Gene: 619830 compounds

RPS6KB1 (ribosomal protein S6 kinase B1) is targeted by 30 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting RPS6KB1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	alvocidib	4.52	91
2	foretinib	4.34	76
3	vandetanib	4.30	73
4	bosutinib	4.08	58
5	midostaurin	3.85	46
6	nintedanib	3.61	36
7	tae 684	3.43	30
8	fedratinib	3.40	29
9	linifanib	3.33	27
10	bisindolylmaleimide ix	3.14	22
11	dovitinib	3.09	21
12	at 9283	3.09	21
13	lestaurtinib	3.04	20
14	pf 03758309	3.00	19
15	ruboxistaurin	2.94	18
16	defosbarasertib	2.89	17
17	pha 665752	2.71	14
18	kw 2449	2.64	13
19	ast 487	2.56	12
20	su 014813	2.20	8
21	cyc 116	2.08	7
22	enzastaurin	2.08	7
23	prexasertib	2.08	7
24	gsk 180736a	2.08	7
25	uprosertib	1.95	6
26	hydroxyfasudil [Supplementary Concept]	1.10	2
27	alsterpaullone	0.69	1
28	Crizotinib	0.69	1
29	Sorafenib	0.69	1
30	sp600125	0.69	1

About RPS6KB1 as a Drug Target

RPS6KB1 (ribosomal protein S6 kinase B1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 30 compounds with documented RPS6KB1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

RPS6KB1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.