What compounds target RXRA?

BiohacksAI has identified 53 compounds that interact with RXRA (retinoid X receptor alpha). Top compounds include: Dehydroepiandrosterone Sulfate, methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept], Sulindac, Thyroxine, Progesterone. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is RXRA (retinoid X receptor)?

RXRA is retinoid X receptor alpha. It is a molecular target for 53 compounds documented in PubMed bioassay data. UniProt ID: P19793. NCBI Gene ID: 6256.

RXRA

MOLECULAR TARGET

retinoid X receptor alpha

UniProt: P19793 NCBI Gene: 625653 compounds

RXRA (retinoid X receptor alpha) is targeted by 53 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting RXRA

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Dehydroepiandrosterone Sulfate	1.95	6
2	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	1.39	3
3	Sulindac	1.39	3
4	Thyroxine	1.10	2
5	Progesterone	1.10	2
6	Vitamin	1.10	2
7	Aldosterone	1.10	2
8	Calcitriol	1.10	2
9	Dactinomycin	1.10	2
10	Domperidone	1.10	2
11	Ethylene Chlorohydrin Used as	1.10	2
12	Phenol	1.10	2
13	Retinaldehyde	1.10	2
14	Ribitol	1.10	2
15	Sorbic Acid Mold and yeast inhibitor. Used as	1.10	2
16	Stavudine	1.10	2
17	Sulfanilamide	1.10	2
18	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	1.10	2
19	Thyroxine	1.10	2
20	Xylitol	1.10	2
21	Arachidonic Acid	0.69	1
22	Genistein	0.69	1
23	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	0.69	1
24	Quercetin	0.69	1
25	Testosterone	0.69	1
26	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	0.69	1
27	Acetylcysteine	0.69	1
28	Adenosine	0.69	1
29	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	0.69	1
30	Chloral Hydrate	0.69	1
31	Chloralose	0.69	1
32	Cilostazol	0.69	1
33	Diflubenzuron	0.69	1
34	Dihydrotestosterone	0.69	1
35	dimethyl formamide	0.69	1
36	Dimethylformamide	0.69	1
37	Diuron	0.69	1
38	Ethidium	0.69	1
39	Ezetimibe	0.69	1
40	Flutamide	0.69	1
41	Gemfibrozil	0.69	1
42	Lutein	0.69	1
43	Niclosamide	0.69	1
44	Niflumic Acid	0.69	1
45	Nitrofurazone	0.69	1
46	Oxaprozin	0.69	1
47	Piperazine	0.69	1
48	Rosuvastatin Calcium	0.69	1
49	Rotenone	0.69	1
50	Sulfamethazine	0.69	1

Showing top 50 of 53 compounds. Use the BiohacksAI search to explore all RXRA modulators.

About RXRA as a Drug Target

RXRA (retinoid X receptor alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 53 compounds with documented RXRA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

RXRA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.