SCN9A
MOLECULAR TARGETsodium voltage-gated channel alpha subunit 9
SCN9A (sodium voltage-gated channel alpha subunit 9) is targeted by 14 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting SCN9A
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | carbamazepine | 5.34 | 208 |
| 2 | mibefradil | 4.26 | 70 |
| 3 | safinamide | 4.13 | 61 |
| 4 | mexiletine | 3.99 | 53 |
| 5 | tetrodotoxin | 3.14 | 22 |
| 6 | pf 05089771 | 2.40 | 10 |
| 7 | mexiletine hydrochloride | 1.95 | 6 |
| 8 | Lacosamide | 0.69 | 1 |
| 9 | Lidocaine | 0.69 | 1 |
| 10 | Saxitoxin | 0.69 | 1 |
| 11 | Veratridine | 0.69 | 1 |
| 12 | bdb n 7 3r 5r 7r adamantan 1 ylmethoxy 6 cyclopropyl 1 2 4 triazolo 4 3 a pyridin 3 | 0.69 | 1 |
| 13 | bdb n 7 adamantan 1 ylmethoxy 6 ethyl 1 2 4 triazolo 4 3 a pyridin 3 yl cyclopropane | 0.69 | 1 |
| 14 | bdb chembl4447021 | 0.69 | 1 |
About SCN9A as a Drug Target
SCN9A (sodium voltage-gated channel alpha subunit 9) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 14 compounds with documented SCN9A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
SCN9A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.