What compounds target SHBG?

BiohacksAI has identified 35 compounds that interact with SHBG (sex hormone binding globulin). Top compounds include: Dihydrotestosterone, Testosterone, Hydrocortisone, Dehydroepiandrosterone, Kaempferols. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SHBG (sex hormone binding)?

SHBG is sex hormone binding globulin. It is a molecular target for 35 compounds documented in PubMed bioassay data. UniProt ID: P04278. NCBI Gene ID: 6462.

SHBG

MOLECULAR TARGET

sex hormone binding globulin

UniProt: P04278 NCBI Gene: 646235 compounds

SHBG (sex hormone binding globulin) is targeted by 35 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SHBG

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Dihydrotestosterone	1.39	3
2	Testosterone	1.10	2
3	Hydrocortisone	0.69	1
4	Dehydroepiandrosterone	0.69	1
5	Kaempferols	0.69	1
6	Progesterone	0.69	1
7	17-alpha-Hydroxypregnenolone	0.69	1
8	17-alpha-Hydroxyprogesterone	0.69	1
9	2-Methoxyestradiol	0.69	1
10	Aldosterone	0.69	1
11	Androstenediol	0.69	1
12	Androstenedione	0.69	1
13	Androsterone	0.69	1
14	Corticosterone	0.69	1
15	Cortisone	0.69	1
16	Danazol	0.69	1
17	Dehydroepiandrosterone	0.69	1
18	Desogestrel	0.69	1
19	Desoxycorticosterone	0.69	1
20	Equilenin	0.69	1
21	Equilin	0.69	1
22	Estriol	0.69	1
23	Estrone	0.69	1
24	Ethinyl Estradiol	0.69	1
25	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	0.69	1
26	Etiocholanolone	0.69	1
27	Gestrinone	0.69	1
28	Hydrocortisone	0.69	1
29	secoisolariciresinol dehydrogenase [Supplementary Concept] catalyzes	0.69	1
30	Medroxyprogesterone Acetate	0.69	1
31	Mesterolone 17 beta-Hydroxy-1 alpha-methyl-5 alpha-androstan-3-one.	0.69	1
32	Methyltestosterone	0.69	1
33	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	0.69	1
34	Norethindrone	0.69	1
35	Pregnenolone	0.69	1

About SHBG as a Drug Target

SHBG (sex hormone binding globulin) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 35 compounds with documented SHBG interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SHBG inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.