SIK1
MOLECULAR TARGETsalt inducible kinase 1
SIK1 (salt inducible kinase 1) is targeted by 20 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting SIK1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | foretinib | 4.34 | 76 |
| 2 | tozasertib | 4.33 | 75 |
| 3 | vandetanib | 4.30 | 73 |
| 4 | bosutinib | 4.08 | 58 |
| 5 | midostaurin | 3.85 | 46 |
| 6 | pazopanib | 3.69 | 39 |
| 7 | neratinib | 3.66 | 38 |
| 8 | nintedanib | 3.61 | 36 |
| 9 | tae 684 | 3.43 | 30 |
| 10 | fedratinib | 3.40 | 29 |
| 11 | mln 8054 | 3.33 | 27 |
| 12 | jnj 7706621 | 3.09 | 21 |
| 13 | lestaurtinib | 3.04 | 20 |
| 14 | r 406 | 2.83 | 16 |
| 15 | plx 4720 | 2.71 | 14 |
| 16 | kw 2449 | 2.64 | 13 |
| 17 | ast 487 | 2.56 | 12 |
| 18 | su 014813 | 2.20 | 8 |
| 19 | gsk 1070916 | 2.20 | 8 |
| 20 | Dasatinib | 1.10 | 2 |
About SIK1 as a Drug Target
SIK1 (salt inducible kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 20 compounds with documented SIK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
SIK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.