SIRT2
MOLECULAR TARGETsirtuin 2
SIRT2 (sirtuin 2) is targeted by 14 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting SIRT2
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | mangostin | 4.14 | 62 |
| 2 | sirtinol | 3.43 | 30 |
| 3 | gf 109203 | 3.40 | 29 |
| 4 | bisindolylmaleimide ix | 3.14 | 22 |
| 5 | gw305074x | 3.14 | 22 |
| 6 | cambinol | 2.94 | 18 |
| 7 | ro 316233 | 2.83 | 16 |
| 8 | suramin hexasodium | 2.83 | 16 |
| 9 | salermide | 2.56 | 12 |
| 10 | paullone | 2.48 | 11 |
| 11 | oblongifolin c | 2.08 | 7 |
| 12 | anilinobenzamide | 1.79 | 5 |
| 13 | Suramin | 1.10 | 2 |
| 14 | trichostatic acid [Supplementary Concept] related to trichostatin | 1.10 | 2 |
About SIRT2 as a Drug Target
SIRT2 (sirtuin 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 14 compounds with documented SIRT2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
SIRT2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.