SIRT6
MOLECULAR TARGETsirtuin 6
SIRT6 (sirtuin 6) is targeted by 8 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting SIRT6
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | trichostatin | 5.45 | 232 |
| 2 | oleoylethanolamide | 3.53 | 33 |
| 3 | gallocatechin gallate | 3.09 | 21 |
| 4 | catechingallate | 2.77 | 15 |
| 5 | trichostatic acid [Supplementary Concept] related to trichostatin | 1.39 | 3 |
| 6 | Fluvastatin | 1.10 | 2 |
| 7 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | 0.69 | 1 |
| 8 | Quercetin | 0.69 | 1 |
About SIRT6 as a Drug Target
SIRT6 (sirtuin 6) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 8 compounds with documented SIRT6 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
SIRT6 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.