What compounds target SLK?

BiohacksAI has identified 74 compounds that interact with SLK (STE20 like kinase). Top compounds include: gefitinib, erlotinib, sb 203580, lapatinib, foretinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SLK (STE20 like kinase)?

SLK is STE20 like kinase. It is a molecular target for 74 compounds documented in PubMed bioassay data. UniProt ID: Q9H2G2. NCBI Gene ID: 9748.

SLK

MOLECULAR TARGET

STE20 like kinase

UniProt: Q9H2G2 NCBI Gene: 974874 compounds

SLK (STE20 like kinase) is targeted by 74 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SLK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	sb 203580	4.92	136
4	lapatinib	4.84	126
5	foretinib	4.34	76
6	tozasertib	4.33	75
7	vandetanib	4.30	73
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	bi 2536	4.01	54
11	quizartinib	3.99	53
12	midostaurin	3.85	46
13	silmitasertib	3.78	43
14	pazopanib	3.69	39
15	neratinib	3.66	38
16	sb 202190	3.64	37
17	nintedanib	3.61	36
18	canertinib	3.53	33
19	pelitinib	3.50	32
20	tae 684	3.43	30
21	fedratinib	3.40	29
22	gilteritinib	3.40	29
23	linifanib	3.33	27
24	saracatinib	3.33	27
25	at 7519	3.33	27
26	sgi 1776	3.26	25
27	tandutinib	3.22	24
28	sp 600125	3.22	24
29	dovitinib	3.09	21
30	jnj 7706621	3.09	21
31	at 9283	3.09	21
32	lestaurtinib	3.04	20
33	lenvatinib	3.04	20
34	filgotinib	3.04	20
35	ruboxistaurin	2.94	18
36	danusertib	2.94	18
37	r 406	2.83	16
38	k 252a	2.83	16
39	cediranib	2.83	16
40	pf 00562271	2.77	15
41	pha 665752	2.71	14
42	plx 4720	2.71	14
43	apitolisib	2.71	14
44	kw 2449	2.64	13
45	ast 487	2.56	12
46	zotiraciclib	2.56	12
47	raf 265	2.48	11
48	defactinib	2.48	11
49	motesanib	2.48	11
50	brivanib	2.48	11

Showing top 50 of 74 compounds. Use the BiohacksAI search to explore all SLK modulators.

About SLK as a Drug Target

SLK (STE20 like kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 74 compounds with documented SLK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SLK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.