What compounds target SMAD2?

BiohacksAI has identified 49 compounds that interact with SMAD2 (SMAD family member 2). Top compounds include: cycloheximide, Disulfiram, Apigenin 5,7,4'-trihydroxy-flavone,, Kaempferols, Quercetin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SMAD2 (SMAD family member)?

SMAD2 is SMAD family member 2. It is a molecular target for 49 compounds documented in PubMed bioassay data. UniProt ID: Q15796. NCBI Gene ID: 4087.

SMAD2

MOLECULAR TARGET

SMAD family member 2

UniProt: Q15796 NCBI Gene: 408749 compounds

SMAD2 (SMAD family member 2) is targeted by 49 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SMAD2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	cycloheximide	1.39	3
2	Disulfiram	1.39	3
3	Apigenin 5,7,4'-trihydroxy-flavone,	1.10	2
4	Kaempferols	1.10	2
5	Quercetin	1.10	2
6	Azacitidine	1.10	2
7	Azacitidine	1.10	2
8	Colchicine	1.10	2
9	Dactinomycin	1.10	2
10	Danazol	1.10	2
11	Ethidium	1.10	2
12	Flutamide	1.10	2
13	Loratadine	1.10	2
14	Nisoldipine	1.10	2
15	Podophyllotoxin	1.10	2
16	vinblastine sulfate	1.10	2
17	chrysin	0.69	1
18	egcg	0.69	1
19	Fluoxetine	0.69	1
20	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	0.69	1
21	Astemizole Antihistamine drug now withdrawn from	0.69	1
22	Bortezomib	0.69	1
23	Celecoxib	0.69	1
24	Ciclopirox	0.69	1
25	Cladribine	0.69	1
26	Dasatinib	0.69	1
27	Daunorubicin	0.69	1
28	Dinitrochlorobenzene	0.69	1
29	Domperidone	0.69	1
30	Emetine	0.69	1
31	Equilin	0.69	1
32	Ethinyl Estradiol	0.69	1
33	Ezetimibe	0.69	1
34	Idazoxan	0.69	1
35	Lynestrenol	0.69	1
36	Nocodazole Nocodazole is	0.69	1
37	Masoprocol	0.69	1
38	o-Phthalaldehyde	0.69	1
39	Oxyphenbutazone	0.69	1
40	Perphenazine	0.69	1
41	pivampicillin	0.69	1
42	Promethazine	0.69	1
43	Rotenone	0.69	1
44	Salmeterol Xinafoate	0.69	1
45	Sulbactam	0.69	1
46	trequinsin hydrochloride	0.69	1
47	triflupromazine hydrochloride	0.69	1
48	Vincristine	0.69	1
49	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	0.69	1

About SMAD2 as a Drug Target

SMAD2 (SMAD family member 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 49 compounds with documented SMAD2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SMAD2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.