SMN2
MOLECULAR TARGETsurvival of motor neuron 2, centromeric
SMN2 (survival of motor neuron 2, centromeric) is targeted by 18 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting SMN2
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Leflunomide | 1.95 | 6 |
| 2 | Pueraria | 1.39 | 3 |
| 3 | Genistein | 1.39 | 3 |
| 4 | Resveratrol | 1.39 | 3 |
| 5 | Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of | 1.39 | 3 |
| 6 | pd98059 | 1.39 | 3 |
| 7 | Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against | 1.39 | 3 |
| 8 | Apigenin 5,7,4'-trihydroxy-flavone, | 1.10 | 2 |
| 9 | Bromodeoxyuridine | 1.10 | 2 |
| 10 | kenpaullone | 1.10 | 2 |
| 11 | Niclosamide | 1.10 | 2 |
| 12 | trichostatic acid [Supplementary Concept] related to trichostatin | 1.10 | 2 |
| 13 | chrysin | 0.69 | 1 |
| 14 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | 0.69 | 1 |
| 15 | Azauridine | 0.69 | 1 |
| 16 | Lovastatin | 0.69 | 1 |
| 17 | piceatannol | 0.69 | 1 |
| 18 | tyrphostin ag 1295 | 0.69 | 1 |
About SMN2 as a Drug Target
SMN2 (survival of motor neuron 2, centromeric) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 18 compounds with documented SMN2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
SMN2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.