What compounds target STK33?

BiohacksAI has identified 57 compounds that interact with STK33 (serine/threonine kinase 33). Top compounds include: Resveratrol, piceatannol, Sorafenib, myricetin-3-O-galactopyranoside [Supplementary Concept], hydroxyfasudil [Supplementary Concept]. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is STK33 (serine/threonine kinase 33)?

STK33 is serine/threonine kinase 33. It is a molecular target for 57 compounds documented in PubMed bioassay data. UniProt ID: Q9BYT3. NCBI Gene ID: 65975.

STK33

MOLECULAR TARGET

serine/threonine kinase 33

UniProt: Q9BYT3 NCBI Gene: 6597557 compounds

STK33 (serine/threonine kinase 33) is targeted by 57 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting STK33

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Resveratrol	1.61	4
2	piceatannol	1.61	4
3	Sorafenib	1.61	4
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	1.39	3
5	hydroxyfasudil [Supplementary Concept]	1.39	3
6	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.39	3
7	Berberine	0.69	1
8	Fluoxetine	0.69	1
9	plumbagin [Supplementary Concept]	0.69	1
10	Sertraline	0.69	1
11	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	0.69	1
12	ag490	0.69	1
13	alsterpaullone	0.69	1
14	Anisomycin	0.69	1
15	Carduus	0.69	1
16	Astemizole Antihistamine drug now withdrawn from	0.69	1
17	Azathioprine	0.69	1
18	Bromocriptine	0.69	1
19	cardamonin	0.69	1
20	Cerulenin	0.69	1
21	Colchicine	0.69	1
22	cycloheximide	0.69	1
23	Daunorubicin	0.69	1
24	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
25	Digitoxin	0.69	1
26	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
27	Digoxin	0.69	1
28	Disulfiram	0.69	1
29	Emetine	0.69	1
30	Ethylmaleimide	0.69	1
31	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	0.69	1
32	Flunarizine Flunarizine is	0.69	1
33	Fluspirilene	0.69	1
34	Hexachlorophene	0.69	1
35	kenpaullone	0.69	1
36	KN 92 [Supplementary Concept] KN 93 isomer;	0.69	1
37	Lovastatin	0.69	1
38	ly294002	0.69	1
39	Melphalan	0.69	1
40	Metergoline	0.69	1
41	Mometasone Furoate	0.69	1
42	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	0.69	1
43	Niclosamide	0.69	1
44	Nocodazole Nocodazole is	0.69	1
45	Ouabain	0.69	1
46	piericidin	0.69	1
47	Podophyllotoxin	0.69	1
48	Puromycin	0.69	1
49	scriptaid	0.69	1
50	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	0.69	1

Showing top 50 of 57 compounds. Use the BiohacksAI search to explore all STK33 modulators.

About STK33 as a Drug Target

STK33 (serine/threonine kinase 33) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 57 compounds with documented STK33 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

STK33 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.