What compounds target TDP1?

BiohacksAI has identified 241 compounds that interact with TDP1 (TDP1 protein (human)). Top compounds include: Disulfiram, Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of, Podophyllotoxin, Progesterone, Nocodazole Nocodazole is. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TDP1 (TDP1 protein (human))?

TDP1 is TDP1 protein (human). It is a molecular target for 241 compounds documented in PubMed bioassay data. UniProt ID: AAI07878.

TDP1

MOLECULAR TARGET

TDP1 protein (human)

UniProt: AAI07878241 compounds

TDP1 (TDP1 protein (human)) is targeted by 241 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TDP1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Disulfiram	2.40	10
2	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	2.30	9
3	Podophyllotoxin	2.30	9
4	Progesterone	2.20	8
5	Nocodazole Nocodazole is	2.20	8
6	Resveratrol	2.08	7
7	Chloramphenicol	2.08	7
8	Nitrofurazone	2.08	7
9	2-Chloroadenosine 2-Chloroadenosine.	1.95	6
10	Methotrexate	1.95	6
11	Astemizole Antihistamine drug now withdrawn from	1.95	6
12	Azacitidine	1.95	6
13	Azacitidine	1.95	6
14	Ciclopirox	1.95	6
15	Cladribine	1.95	6
16	cycloheximide	1.95	6
17	Dideoxyadenosine	1.95	6
18	Digoxin	1.95	6
19	Ethidium	1.95	6
20	Flutamide	1.95	6
21	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	1.95	6
22	Hexachlorophene	1.95	6
23	mg624	1.95	6
24	Niclosamide	1.95	6
25	Oxyphenbutazone	1.95	6
26	tyrphostin 9	1.95	6
27	vinblastine sulfate	1.95	6
28	Quercetin	1.79	5
29	Camptothecin	1.79	5
30	Clotrimazole	1.79	5
31	Colchicine	1.79	5
32	Dihydroergocristine	1.79	5
33	Loratadine	1.79	5
34	ly294002	1.79	5
35	sp600125	1.79	5
36	Methylene Blue	1.61	4
37	plumbagin [Supplementary Concept]	1.61	4
38	2-Methoxyestradiol	1.61	4
39	6-Aminonicotinamide	1.61	4
40	Bortezomib	1.61	4
41	Carbidopa	1.61	4
42	clofilium tosylate	1.61	4
43	colchine	1.61	4
44	Cytarabine	1.61	4
45	Dasatinib	1.61	4
46	Daunorubicin	1.61	4
47	Decitabine	1.61	4
48	Demecolcine	1.61	4
49	Dequalinium	1.61	4
50	Didanosine	1.61	4

Showing top 50 of 241 compounds. Use the BiohacksAI search to explore all TDP1 modulators.

About TDP1 as a Drug Target

TDP1 (TDP1 protein (human)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 241 compounds with documented TDP1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TDP1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.