What compounds target THRB?

BiohacksAI has identified 230 compounds that interact with THRB (thyroid hormone receptor beta). Top compounds include: Triiodothyronine, Hexachlorophene, Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less, Rotenone, Thyroxine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is THRB (thyroid hormone receptor)?

THRB is thyroid hormone receptor beta. It is a molecular target for 230 compounds documented in PubMed bioassay data. UniProt ID: NP_001257783. NCBI Gene ID: 24831.

THRB

MOLECULAR TARGET

thyroid hormone receptor beta

UniProt: NP_001257783 NCBI Gene: 24831230 compounds

THRB (thyroid hormone receptor beta) is targeted by 230 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting THRB

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Triiodothyronine	3.71	40
2	Hexachlorophene	1.95	6
3	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	1.95	6
4	Rotenone	1.95	6
5	Thyroxine	1.79	5
6	Daunorubicin	1.79	5
7	Ethidium	1.79	5
8	Thyroxine	1.79	5
9	Budesonide	1.61	4
10	Methylene Blue	1.61	4
11	Progesterone	1.61	4
12	Colchicine	1.61	4
13	Ethinyl Estradiol	1.61	4
14	Melengestrol Acetate	1.61	4
15	Methyltestosterone	1.61	4
16	Norethindrone	1.61	4
17	Genistein	1.39	3
18	Androstenedione	1.39	3
19	Celecoxib	1.39	3
20	Chlorhexidine	1.39	3
21	cycloheximide	1.39	3
22	Dextrothyroxine	1.39	3
23	Dihydrotestosterone	1.39	3
24	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	1.39	3
25	o-Phthalaldehyde	1.39	3
26	Oxymetholone	1.39	3
27	Podophyllotoxin	1.39	3
28	Reserpine	1.39	3
29	Spironolactone	1.39	3
30	vinblastine sulfate	1.39	3
31	Vorinostat	1.39	3
32	Apigenin 5,7,4'-trihydroxy-flavone,	1.10	2
33	Azithromycin	1.10	2
34	Dehydroepiandrosterone	1.10	2
35	egcg	1.10	2
36	Resveratrol	1.10	2
37	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	1.10	2
38	Testosterone	1.10	2
39	vinpocetine	1.10	2
40	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.10	2
41	Acetaldehyde	1.10	2
42	Methotrexate	1.10	2
43	Ammonia	1.10	2
44	Amoxapine	1.10	2
45	Arsenic Trioxide	1.10	2
46	Astemizole Antihistamine drug now withdrawn from	1.10	2
47	Azacitidine	1.10	2
48	Azacitidine	1.10	2
49	Bortezomib	1.10	2
50	Carbazilquinone	1.10	2

Showing top 50 of 230 compounds. Use the BiohacksAI search to explore all THRB modulators.

About THRB as a Drug Target

THRB (thyroid hormone receptor beta) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 230 compounds with documented THRB interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

THRB inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.