What compounds target TNIK?

BiohacksAI has identified 51 compounds that interact with TNIK (TRAF2 and NCK interacting kinase). Top compounds include: gefitinib, erlotinib, sb 203580, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TNIK (TRAF2 and NCK)?

TNIK is TRAF2 and NCK interacting kinase. It is a molecular target for 51 compounds documented in PubMed bioassay data. UniProt ID: Q9UKE5. NCBI Gene ID: 23043.

TNIK

MOLECULAR TARGET

TRAF2 and NCK interacting kinase

UniProt: Q9UKE5 NCBI Gene: 2304351 compounds

TNIK (TRAF2 and NCK interacting kinase) is targeted by 51 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TNIK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	sb 203580	4.92	136
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	vandetanib	4.30	73
7	ponatinib	4.26	70
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	quizartinib	3.99	53
11	midostaurin	3.85	46
12	pazopanib	3.69	39
13	neratinib	3.66	38
14	sb 202190	3.64	37
15	nintedanib	3.61	36
16	canertinib	3.53	33
17	pelitinib	3.50	32
18	tae 684	3.43	30
19	linifanib	3.33	27
20	saracatinib	3.33	27
21	sp 600125	3.22	24
22	dovitinib	3.09	21
23	at 9283	3.09	21
24	lestaurtinib	3.04	20
25	pacritinib	3.04	20
26	lenvatinib	3.04	20
27	ruboxistaurin	2.94	18
28	galunisertib	2.94	18
29	defosbarasertib	2.89	17
30	orantinib	2.89	17
31	r 406	2.83	16
32	k 252a	2.83	16
33	cediranib	2.83	16
34	milciclib	2.77	15
35	sotrastaurin	2.77	15
36	pha 665752	2.71	14
37	plx 4720	2.71	14
38	crenolanib	2.71	14
39	kw 2449	2.64	13
40	ast 487	2.56	12
41	raf 265	2.48	11
42	brivanib	2.48	11
43	azd 7762	2.30	9
44	su 014813	2.20	8
45	rebastinib	2.20	8
46	cyc 116	2.08	7
47	pf 03814735	1.79	5
48	Axitinib	1.10	2
49	Dasatinib	0.69	1
50	Sorafenib	0.69	1

Showing top 50 of 51 compounds. Use the BiohacksAI search to explore all TNIK modulators.

About TNIK as a Drug Target

TNIK (TRAF2 and NCK interacting kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 51 compounds with documented TNIK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TNIK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.