TNKS2
MOLECULAR TARGETtankyrase 2
TNKS2 (tankyrase 2) is targeted by 13 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting TNKS2
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | olaparib | 4.70 | 109 |
| 2 | flavone | 4.34 | 76 |
| 3 | midostaurin | 3.85 | 46 |
| 4 | rucaparib | 3.58 | 35 |
| 5 | veliparib | 3.47 | 31 |
| 6 | niraparib | 3.30 | 26 |
| 7 | lestaurtinib | 3.04 | 20 |
| 8 | pj34 | 2.64 | 13 |
| 9 | atamparib | 2.30 | 9 |
| 10 | 2x 121 | 1.95 | 6 |
| 11 | pamiparib | 1.79 | 5 |
| 12 | Apigenin 5,7,4'-trihydroxy-flavone, | 1.10 | 2 |
| 13 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | 1.10 | 2 |
About TNKS2 as a Drug Target
TNKS2 (tankyrase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 13 compounds with documented TNKS2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
TNKS2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.