TOP2A
MOLECULAR TARGETDNA topoisomerase II alpha
TOP2A (DNA topoisomerase II alpha) is targeted by 14 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting TOP2A
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | myricetin-3-O-galactopyranoside [Supplementary Concept] | 1.61 | 4 |
| 2 | Daunorubicin | 1.61 | 4 |
| 3 | Genistein | 1.10 | 2 |
| 4 | Quercetin | 1.10 | 2 |
| 5 | Ethidium | 1.10 | 2 |
| 6 | Teniposide | 1.10 | 2 |
| 7 | Topotecan | 1.10 | 2 |
| 8 | Ciprofloxacin | 0.69 | 1 |
| 9 | fisetin | 0.69 | 1 |
| 10 | Aclarubicin | 0.69 | 1 |
| 11 | Dexrazoxane | 0.69 | 1 |
| 12 | Digitoxin | 0.69 | 1 |
| 13 | Epirubicin | 0.69 | 1 |
| 14 | Idarubicin | 0.69 | 1 |
About TOP2A as a Drug Target
TOP2A (DNA topoisomerase II alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 14 compounds with documented TOP2A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
TOP2A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.