TOP2B
MOLECULAR TARGETDNA topoisomerase II beta
TOP2B (DNA topoisomerase II beta) is targeted by 8 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting TOP2B
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | amsacrine | 4.82 | 123 |
| 2 | decernotinib | 2.20 | 8 |
| 3 | amg 900 | 2.08 | 7 |
| 4 | azd 8186 | 1.79 | 5 |
| 5 | Digitoxin | 1.10 | 2 |
| 6 | Topotecan | 1.10 | 2 |
| 7 | Ciprofloxacin | 0.69 | 1 |
| 8 | Ethidium | 0.69 | 1 |
About TOP2B as a Drug Target
TOP2B (DNA topoisomerase II beta) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 8 compounds with documented TOP2B interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
TOP2B inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.