What compounds target TP53?

BiohacksAI has identified 151 compounds that interact with TP53 (tumor protein p53). Top compounds include: Ethidium, Ethinyl Estradiol, Hexachlorophene, Azacitidine, Azacitidine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TP53 (tumor protein p53)?

TP53 is tumor protein p53. It is a molecular target for 151 compounds documented in PubMed bioassay data. UniProt ID: P04637. NCBI Gene ID: 7157.

TP53

MOLECULAR TARGET

tumor protein p53

UniProt: P04637 NCBI Gene: 7157151 compounds

TP53 (tumor protein p53) is targeted by 151 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TP53

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Ethidium	2.77	15
2	Ethinyl Estradiol	2.71	14
3	Hexachlorophene	2.71	14
4	Azacitidine	2.56	12
5	Azacitidine	2.56	12
6	Methylene Blue	2.48	11
7	Bortezomib	2.40	10
8	Rotenone	2.40	10
9	Azathioprine	2.30	9
10	Cladribine	2.30	9
11	Apigenin 5,7,4'-trihydroxy-flavone,	2.20	8
12	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	2.20	8
13	Cytarabine	2.20	8
14	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	2.20	8
15	Melphalan	2.20	8
16	Niclosamide	2.20	8
17	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	2.20	8
18	Methotrexate	2.08	7
19	Dactinomycin	2.08	7
20	Daunorubicin	2.08	7
21	Disulfiram	2.08	7
22	Glutaral	2.08	7
23	Vitamin K 3	2.08	7
24	Trifluridine	2.08	7
25	Quercetin	1.95	6
26	Axitinib	1.95	6
27	ninhydrin	1.95	6
28	o-Phthalaldehyde	1.95	6
29	Razoxane	1.95	6
30	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.95	6
31	plumbagin [Supplementary Concept]	1.79	5
32	Camptothecin	1.79	5
33	Reserpine	1.79	5
34	Genistein	1.61	4
35	Resveratrol	1.61	4
36	Ciclopirox	1.61	4
37	Clofarabine	1.61	4
38	cycloheximide	1.61	4
39	daph	1.61	4
40	Dinitrochlorobenzene	1.61	4
41	Estramustine	1.61	4
42	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	1.61	4
43	Loratadine	1.61	4
44	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.61	4
45	Riluzole	1.61	4
46	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	1.61	4
47	Trabectedin	1.61	4
48	Vorinostat	1.61	4
49	Clotrimazole	1.39	3
50	Demeclocycline	1.39	3

Showing top 50 of 151 compounds. Use the BiohacksAI search to explore all TP53 modulators.

About TP53 as a Drug Target

TP53 (tumor protein p53) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 151 compounds with documented TP53 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TP53 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.