What compounds target TYK2?

BiohacksAI has identified 66 compounds that interact with TYK2 (tyrosine kinase 2). Top compounds include: erlotinib, imatinib, sb 203580, tofacitinib, alvocidib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TYK2 (tyrosine kinase 2)?

TYK2 is tyrosine kinase 2. It is a molecular target for 66 compounds documented in PubMed bioassay data. UniProt ID: P29597. NCBI Gene ID: 7297.

TYK2

MOLECULAR TARGET

tyrosine kinase 2

UniProt: P29597 NCBI Gene: 729766 compounds

TYK2 (tyrosine kinase 2) is targeted by 66 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TYK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	imatinib	5.47	236
3	sb 203580	4.92	136
4	tofacitinib	4.65	104
5	alvocidib	4.52	91
6	foretinib	4.34	76
7	tozasertib	4.33	75
8	ruxolitinib	4.23	68
9	pi 103	4.17	64
10	bosutinib	4.08	58
11	midostaurin	3.85	46
12	silmitasertib	3.78	43
13	pazopanib	3.69	39
14	nintedanib	3.61	36
15	baricitinib	3.56	34
16	6bio	3.50	32
17	tae 684	3.43	30
18	fedratinib	3.40	29
19	dovitinib	3.09	21
20	jnj 7706621	3.09	21
21	at 9283	3.09	21
22	upadacitinib	3.09	21
23	lestaurtinib	3.04	20
24	pacritinib	3.04	20
25	filgotinib	3.04	20
26	momelotinib	2.89	17
27	r 406	2.83	16
28	infigratinib	2.77	15
29	hesperadin	2.77	15
30	pha 665752	2.71	14
31	enmd 2076	2.71	14
32	bms 345541	2.71	14
33	kw 2449	2.64	13
34	ast 487	2.56	12
35	raf 265	2.48	11
36	defactinib	2.48	11
37	deucravacitinib	2.48	11
38	azd 1480	2.30	9
39	reversine	2.30	9
40	su 014813	2.20	8
41	decernotinib	2.20	8
42	gandotinib	2.20	8
43	cyc 116	2.08	7
44	tg100 115	2.08	7
45	cerdulatinib	1.95	6
46	itacitinib	1.95	6
47	delgocitinib	1.95	6
48	pf 03814735	1.79	5
49	abrocitinib	1.79	5
50	Crizotinib	1.39	3

Showing top 50 of 66 compounds. Use the BiohacksAI search to explore all TYK2 modulators.

About TYK2 as a Drug Target

TYK2 (tyrosine kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 66 compounds with documented TYK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TYK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.