TYMS
MOLECULAR TARGETthymidylate synthetase
TYMS (thymidylate synthetase) is targeted by 10 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting TYMS
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | methotrexate | 6.00 | 404 |
| 2 | raltitrexed | 3.58 | 35 |
| 3 | Pemetrexed | 3.04 | 20 |
| 4 | Fluorodeoxyuridylate 5-Fluoro-2'-deoxyuridylate. | 2.83 | 16 |
| 5 | phenolphthalein | 2.30 | 9 |
| 6 | Methotrexate | 1.39 | 3 |
| 7 | Capecitabine | 1.10 | 2 |
| 8 | Cytarabine | 0.69 | 1 |
| 9 | Thymidine Monophosphate 5-Thymidylic acid. | 0.69 | 1 |
| 10 | Trifluridine | 0.69 | 1 |
About TYMS as a Drug Target
TYMS (thymidylate synthetase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 10 compounds with documented TYMS interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
TYMS inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.