What compounds target TYROSINE-PROTEIN?

BiohacksAI has identified 201 compounds that interact with TYROSINE-PROTEIN (Tyrosine-protein kinase SYK (human)). Top compounds include: Dasatinib, Crizotinib, Imatinib Mesylate, Methotrexate, Ursolic Acid. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TYROSINE-PROTEIN (Tyrosine-protein kinase SYK)?

TYROSINE-PROTEIN is Tyrosine-protein kinase SYK (human). It is a molecular target for 201 compounds documented in PubMed bioassay data. UniProt ID: P43405.

TYROSINE-PROTEIN

MOLECULAR TARGET

Tyrosine-protein kinase SYK (human)

UniProt: P43405201 compounds

TYROSINE-PROTEIN (Tyrosine-protein kinase SYK (human)) is targeted by 201 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TYROSINE-PROTEIN

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Dasatinib	4.29	72
2	Crizotinib	2.89	17
3	Imatinib Mesylate	2.30	9
4	Methotrexate	2.20	8
5	Ursolic Acid	2.08	7
6	Axitinib	2.08	7
7	piceatannol	2.08	7
8	sp600125	2.08	7
9	Afatinib	1.95	6
10	ag490	1.95	6
11	Ouabain	1.95	6
12	celastrol	1.79	5
13	Niclosamide	1.79	5
14	Simvastatin	1.61	4
15	alpelisib	1.61	4
16	Chlorhexidine	1.61	4
17	Clofarabine	1.61	4
18	Colchicine	1.61	4
19	cycloheximide	1.61	4
20	deguelin [Supplementary Concept]	1.61	4
21	Digoxin	1.61	4
22	Disulfiram	1.61	4
23	Emetine	1.61	4
24	Ezetimibe	1.61	4
25	Hexachlorophene	1.61	4
26	Lovastatin	1.61	4
27	Medroxyprogesterone Acetate	1.61	4
28	Melphalan	1.61	4
29	Mometasone Furoate	1.61	4
30	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.61	4
31	Podophyllotoxin	1.61	4
32	Thapsigargin	1.61	4
33	torin 1	1.61	4
34	trichostatic acid [Supplementary Concept] related to trichostatin	1.61	4
35	Trifluridine	1.61	4
36	tyrphostin ag 1478	1.61	4
37	Astemizole Antihistamine drug now withdrawn from	1.39	3
38	Avapritinib	1.39	3
39	Azathioprine	1.39	3
40	Bortezomib	1.39	3
41	Epirubicin	1.39	3
42	Maprotiline	1.39	3
43	Nocodazole Nocodazole is	1.39	3
44	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	1.39	3
45	pictilisib	1.39	3
46	Tripterygium	1.39	3
47	Vincristine	1.39	3
48	withaferin	1.39	3
49	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.10	2
50	Methylene Blue	1.10	2

Showing top 50 of 201 compounds. Use the BiohacksAI search to explore all TYROSINE-PROTEIN modulators.

About TYROSINE-PROTEIN as a Drug Target

TYROSINE-PROTEIN (Tyrosine-protein kinase SYK (human)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 201 compounds with documented TYROSINE-PROTEIN interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TYROSINE-PROTEIN inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.