gsk vs hydroxyfasudil
Mechanistic comparison of gsk 690693 and hydroxyfasudil [Supplementary Concept] based on molecular target overlap from BindingDB and ChEMBL binding affinity data.
21
Shared Targets
18%
Jaccard Similarity
17%
IDF-Weighted Similarity
Jaccard measures raw target overlap. IDF-weighted downweights promiscuous hub targets (e.g. CYP enzymes) that bind many compounds non-specifically.
Evidence Comparison
Target Overlap
gsk and hydroxyfasudil share 21 molecular targets based on binding affinity data from BindingDB (Kd/IC50 ≤ 10 µM) and ChEMBL. A Jaccard index of 0.178 means 18% of the combined target set is bound by both compounds. The IDF-weighted score of 0.175 accounts for non-specific binding to metabolic enzymes.
Note: High target overlap does not imply identical mechanism or therapeutic equivalence. Binding affinity, tissue distribution, bioavailability, and downstream signaling differ significantly between compounds even when they bind the same protein.