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Hesperidin vs isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside

Mechanistic comparison of Hesperidin and isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from based on molecular target overlap from BindingDB and ChEMBL binding affinity data.

11
Shared Targets
28%
Jaccard Similarity
24%
IDF-Weighted Similarity
Jaccard measures raw target overlap. IDF-weighted downweights promiscuous hub targets (e.g. CYP enzymes) that bind many compounds non-specifically.

Evidence Comparison

Hesperidin
—
Evidence Score
300
PubMed Studies
View full profile →
isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from
—
Evidence Score
300
PubMed Studies
View full profile →

Target Overlap

Hesperidin and isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside share 11 molecular targets based on binding affinity data from BindingDB (Kd/IC50 ≤ 10 µM) and ChEMBL. A Jaccard index of 0.282 means 28% of the combined target set is bound by both compounds. The IDF-weighted score of 0.239 accounts for non-specific binding to metabolic enzymes.

Note: High target overlap does not imply identical mechanism or therapeutic equivalence. Binding affinity, tissue distribution, bioavailability, and downstream signaling differ significantly between compounds even when they bind the same protein.

Frequently Asked Questions

What do Hesperidin and isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside have in common?
Hesperidin and isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside share 11 molecular targets with a Jaccard similarity of 28%. Both bind overlapping sets of proteins based on BindingDB and ChEMBL binding affinity data.
Can Hesperidin and isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside be combined?
Hesperidin and isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside share 11 molecular targets, suggesting potential pathway overlap. Combination use should be evaluated with a qualified healthcare professional. BiohacksAI does not provide medical advice.
Which has more research: Hesperidin or isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside?
In the BiohacksAI corpus: Hesperidin has 300 PubMed-indexed studies, isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside has 300 studies.

Related Comparisons

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Hesperidin vs Kaempferols10 targetsHesperidin vs biochanin5 targetsHesperidin vs galangin6 targetsHesperidin vs tiliroside4 targetsHesperidin vs 4-Hydroxybenzoate-3-Monooxygenase6 targets

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View full Hesperidin profile →View full isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside profile →Browse all substances →