Thioinosine vs Tilorone
Mechanistic comparison of Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes and Tilorone based on molecular target overlap from BindingDB and ChEMBL binding affinity data.
9
Shared Targets
27%
Jaccard Similarity
24%
IDF-Weighted Similarity
Jaccard measures raw target overlap. IDF-weighted downweights promiscuous hub targets (e.g. CYP enzymes) that bind many compounds non-specifically.
Evidence Comparison
Target Overlap
Thioinosine and Tilorone share 9 molecular targets based on binding affinity data from BindingDB (Kd/IC50 ≤ 10 µM) and ChEMBL. A Jaccard index of 0.273 means 27% of the combined target set is bound by both compounds. The IDF-weighted score of 0.241 accounts for non-specific binding to metabolic enzymes.
Note: High target overlap does not imply identical mechanism or therapeutic equivalence. Binding affinity, tissue distribution, bioavailability, and downstream signaling differ significantly between compounds even when they bind the same protein.