What compounds affect the Cellular response to hypoxia pathway?

99 compounds in the BiohacksAI corpus have documented interactions with genes in the Cellular response to hypoxia pathway (Reactome ID: R-HSA-1234174). These compounds target 39 genes within this pathway.

What genes are in the Cellular response to hypoxia pathway?

The Cellular response to hypoxia pathway involves 39 genes. Key genes include: ADRM1, ARNT, CA9, CREBBP, EP300, EPAS1, HIF1A, PSMA1, PSMA2, PSMA3.

Cellular response to hypoxia

REACTOME PATHWAY

Reactome: R-HSA-123417439 genes99 compounds

The Cellular response to hypoxia pathway (Reactome ID: R-HSA-1234174) involves 39 genes and is affected by 99 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ARNT CA9 CREBBP EP300 EPAS1 HIF1A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+9 more

Compounds Affecting Cellular response to hypoxia

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	chrysin	—	300
4	egcg	—	300
5	Quercetin	—	300
6	Emetine	—	298
7	cycloheximide	—	300
8	Topotecan	—	300
9	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
10	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
11	Harmaline	—	300
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Resveratrol	—	298
14	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
15	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
16	Digoxin	—	299
17	gedunin	—	54
18	Oxytetracycline	—	300
19	Tubercidin	—	300
20	ninhydrin	—	300
21	4-Hydroxybenzoate-3-Monooxygenase	—	300
22	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
23	Gliotoxin	—	300
24	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
25	Loratadine	—	296
26	oxatomide [Supplementary Concept] structure;	—	128
27	triolimus [Supplementary Concept]	—	33
28	Hydrocortisone	—	299
29	Kaempferols	—	300
30	2-Chloroadenosine 2-Chloroadenosine.	—	300
31	ag490	—	14
32	Beclomethasone	—	300
33	Camptothecin	—	300
34	celastrol	—	300
35	Clotrimazole	—	296
36	cycloserine	—	298
37	Dequalinium	—	136
38	Desoximetasone	—	86
39	Epinephrine	—	299
40	Ethoxyquin Antioxidant; also	—	180
41	Fusaric Acid	—	300
42	Hesperidin	—	300
43	Hydrocortisone	—	298
44	Mometasone Furoate	—	292
45	Niclosamide	—	299
46	Nisoldipine	—	297
47	Phenoxybenzamine	—	21
48	sp600125	—	117
49	tyrphostin 9	—	2
50	Sulfanilamide	—	300

About the Cellular response to hypoxia Pathway

The Cellular response to hypoxia pathway is catalogued in Reactome (ID: R-HSA-1234174) and involves 39 genes. In the BiohacksAI corpus, 99 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ARNT, CA9, CREBBP, EP300.