What compounds affect the Signaling by ERBB4 pathway?

386 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by ERBB4 pathway (Reactome ID: R-HSA-1236394). These compounds target 26 genes within this pathway.

What genes are in the Signaling by ERBB4 pathway?

The Signaling by ERBB4 pathway involves 26 genes. Key genes include: ADAM17, APH1A, APH1B, EGFR, ERBB3, ERBB4, ESR1, GABRA1, GABRB1, GABRB2.

Signaling by ERBB4

REACTOME PATHWAY

Reactome: R-HSA-123639426 genes386 compounds

The Signaling by ERBB4 pathway (Reactome ID: R-HSA-1236394) involves 26 genes and is affected by 386 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM17 APH1A APH1B EGFR ERBB3 ERBB4 ESR1 GABRA1 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GRB2 NCOR1 NCSTN PGR PIK3R1 PSEN1 PSEN2 PSENEN S100B SRC STAT5A YAP1

Compounds Affecting Signaling by ERBB4

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	chrysin	—	300
3	Triiodothyronine	—	300
4	Pregnanolone	—	298
5	Androsterone	—	300
6	gamma-Aminobutyric Acid	—	300
7	Bicuculline	—	300
8	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
9	Dasatinib	—	299
10	Ciprofloxacin	—	1,000
11	Etiocholanolone	—	300
12	Ondansetron	—	299
13	Picrotoxin	—	300
14	Dihydroergocristine	—	187
15	Resveratrol	—	298
16	Dactinomycin	—	297
17	Quercetin	—	300
18	Afatinib	—	297
19	Genistein	—	300
20	Kaempferols	—	300
21	Rotenone	—	300
22	cycloheximide	—	300
23	Niclosamide	—	299
24	Daunorubicin	—	298
25	Emetine	—	298
26	Bisphenol A-Glycidyl Methacrylate	—	197
27	Eszopiclone	—	296
28	tyrphostin ag 1478	—	4
29	Levonorgestrel	—	292
30	Norgestrel	—	300
31	Ethinyl Estradiol	—	300
32	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
33	Methyltestosterone	—	300
34	Dehydroepiandrosterone	—	300
35	Dehydroepiandrosterone	—	300
36	Fulvestrant	—	295
37	Danazol	—	298
38	Estrone	—	300
39	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
40	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
41	Dihydrotestosterone	—	300
42	Ethidium	—	300
43	Ethynodiol Diacetate	—	300
44	Flutamide	—	298
45	Colchicine	—	300
46	Estriol	—	300
47	Mestranol	—	300
48	Norethindrone	—	300
49	Oxymetholone	—	298
50	Testosterone Propionate	—	300

About the Signaling by ERBB4 Pathway

The Signaling by ERBB4 pathway is catalogued in Reactome (ID: R-HSA-1236394) and involves 26 genes. In the BiohacksAI corpus, 386 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, APH1A, APH1B, EGFR, ERBB3.