What compounds affect the Potassium Channels pathway?

214 compounds in the BiohacksAI corpus have documented interactions with genes in the Potassium Channels pathway (Reactome ID: R-HSA-1296071). These compounds target 29 genes within this pathway.

What genes are in the Potassium Channels pathway?

The Potassium Channels pathway involves 29 genes. Key genes include: ABCC8, ABCC9, GABBR1, GABBR2, HCN3, KCNA1, KCNA3, KCNA5, KCNA7, KCNB1.

Potassium Channels

REACTOME PATHWAY

Reactome: R-HSA-129607129 genes214 compounds

The Potassium Channels pathway (Reactome ID: R-HSA-1296071) involves 29 genes and is affected by 214 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC8 ABCC9 GABBR1 GABBR2 HCN3 KCNA1 KCNA3 KCNA5 KCNA7 KCNB1 KCNH1 KCNH2 KCNJ1 KCNJ10 KCNJ4 KCNK10 KCNK16 KCNK18 KCNK2 KCNK3 KCNK4 KCNMA1 KCNMB1 KCNMB2 KCNMB4 KCNN1 KCNN3 KCNN4 KCNQ1

Compounds Affecting Potassium Channels

#	Compound	Targets Hit	Studies
1	Carvedilol	—	296
2	Quinidine	—	298
3	Thioridazine	—	35
4	Nisoldipine	—	297
5	Nortriptyline	—	28
6	Arachidonic Acid	—	245
7	Clotrimazole	—	296
8	Perphenazine	—	297
9	Promethazine	—	121
10	Ritonavir	—	298
11	Riluzole	—	298
12	Flecainide	—	297
13	Amoxapine	—	259
14	pterostilbene	—	299
15	Fluocinolone Acetonide	—	295
16	Glyburide	—	298
17	Latanoprost	—	299
18	nafadotride	—	14
19	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
20	Lovastatin	—	300
21	Nicardipine	—	94
22	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
23	Dequalinium	—	136
24	Budesonide	—	1,000
25	Resveratrol	—	298
26	Ethylestrenol	—	70
27	Ezetimibe	—	296
28	Thyroxine	—	994
29	Thyroxine	—	300
30	Astemizole Antihistamine drug now withdrawn from	—	280
31	dofetilide	—	298
32	vinpocetine	—	299
33	Fluspirilene	—	74
34	Duloxetine Hydrochloride	—	993
35	Nitrendipine	—	299
36	Flunarizine Flunarizine is	—	299
37	Oleic Acid	—	112
38	Disulfiram	—	297
39	Miconazole	—	298
40	Testosterone Propionate	—	300
41	Calcimycin	—	216
42	Chlorpheniramine	—	157
43	Flutamide	—	298
44	Nortriptyline	—	295
45	Irbesartan	—	298
46	Simvastatin	—	1,000
47	Calcitriol	—	300
48	Oxcarbazepine	—	296
49	Ursodeoxycholic Acid	—	298
50	Ethinyl Estradiol	—	300

About the Potassium Channels Pathway

The Potassium Channels pathway is catalogued in Reactome (ID: R-HSA-1296071) and involves 29 genes. In the BiohacksAI corpus, 214 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC8, ABCC9, GABBR1, GABBR2, HCN3.