What compounds affect the Voltage gated Potassium channels pathway?

159 compounds in the BiohacksAI corpus have documented interactions with genes in the Voltage gated Potassium channels pathway (Reactome ID: R-HSA-1296072). These compounds target 8 genes within this pathway.

What genes are in the Voltage gated Potassium channels pathway?

The Voltage gated Potassium channels pathway involves 8 genes. Key genes include: KCNA1, KCNA3, KCNA5, KCNA7, KCNB1, KCNH1, KCNH2, KCNQ1.

Voltage gated Potassium channels

REACTOME PATHWAY

Reactome: R-HSA-12960728 genes159 compounds

The Voltage gated Potassium channels pathway (Reactome ID: R-HSA-1296072) involves 8 genes and is affected by 159 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

KCNA1 KCNA3 KCNA5 KCNA7 KCNB1 KCNH1 KCNH2 KCNQ1

Compounds Affecting Voltage gated Potassium channels

#	Compound	Targets Hit	Studies
1	Quinidine	—	298
2	Flecainide	—	297
3	Clotrimazole	—	296
4	Astemizole Antihistamine drug now withdrawn from	—	280
5	dofetilide	—	298
6	vinpocetine	—	299
7	Duloxetine Hydrochloride	—	993
8	Thioridazine	—	35
9	Oleic Acid	—	112
10	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
11	Nisoldipine	—	297
12	Calcimycin	—	216
13	Nortriptyline	—	28
14	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
15	Aripiprazole	—	298
16	Domperidone	—	299
17	Loratadine	—	296
18	Fluoxetine	—	1,000
19	Reserpine	—	297
20	lidoflazine	—	278
21	clofilium tosylate	—	4
22	Fluspirilene	—	74
23	Vincamine	—	300
24	Amoxapine	—	259
25	Fenofibrate	—	297
26	Lumefantrine	—	299
27	Phenoxybenzamine	—	21
28	Cinnarizine	—	299
29	Metergoline	—	144
30	Nitrendipine	—	299
31	Ondansetron	—	299
32	Perphenazine	—	297
33	Rimonabant	—	300
34	Celecoxib	—	295
35	Dibucaine	—	299
36	dilazep	—	300
37	Flunarizine Flunarizine is	—	299
38	Hydroxyzine	—	298
39	Lovastatin	—	300
40	Loxapine	—	30
41	Maprotiline	—	299
42	Vitamin K 3	—	300
43	Nebivolol	—	297
44	Nicergoline	—	300
45	Nylidrin	—	90
46	oxatomide [Supplementary Concept] structure;	—	128
47	Phentolamine	—	300
48	pirenperone	—	22
49	Promazine	—	40
50	Promethazine	—	121

About the Voltage gated Potassium channels Pathway

The Voltage gated Potassium channels pathway is catalogued in Reactome (ID: R-HSA-1296072) and involves 8 genes. In the BiohacksAI corpus, 159 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KCNA1, KCNA3, KCNA5, KCNA7, KCNB1.