What compounds affect the Extracellular matrix organization pathway?

92 compounds in the BiohacksAI corpus have documented interactions with genes in the Extracellular matrix organization pathway (Reactome ID: R-HSA-1474244). These compounds target 41 genes within this pathway.

What genes are in the Extracellular matrix organization pathway?

The Extracellular matrix organization pathway involves 41 genes. Key genes include: ADAM10, ADAM17, ADAMTS4, ADAMTS5, APP, CAPN1, CASK, CD47, CMA1, CTRB1.

Extracellular matrix organization

REACTOME PATHWAY

Reactome: R-HSA-147424441 genes92 compounds

The Extracellular matrix organization pathway (Reactome ID: R-HSA-1474244) involves 41 genes and is affected by 92 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ADAM17 ADAMTS4 ADAMTS5 APP CAPN1 CASK CD47 CMA1 CTRB1 CTSG CTSL DDR1 DDR2 ELANE FURIN ICAM1 ITGA2B ITGA4 ITGAV ITGB2 ITGB3 KDR KLK7 KLKB1 LOX LOXL2 LOXL3 LOXL4 MMP14+11 more

Compounds Affecting Extracellular matrix organization

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	egcg	—	300
3	Disulfiram	—	297
4	Sorafenib	—	300
5	Crizotinib	—	298
6	Resveratrol	—	298
7	Kaempferols	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	piceatannol	—	300
10	Axitinib	—	298
11	Dasatinib	—	299
12	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
13	Quercetin	—	300
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Vitamin	—	295
17	Prednisolone	—	1,000
18	Astemizole Antihistamine drug now withdrawn from	—	280
19	sp600125	—	117
20	Bisphenol A-Glycidyl Methacrylate	—	197
21	Hexachlorophene	—	300
22	Sulfaguanidine	—	255
23	Dihydroergocristine	—	187
24	Gabexate	—	300
25	Lovastatin	—	300
26	Hesperidin	—	300
27	Methylene Blue	—	200
28	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
29	caffeic acid	—	300
30	2-Methoxyestradiol	—	300
31	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
32	Cladribine	—	297
33	Digitoxin	—	300
34	Digoxin	—	299
35	Edetic Acid	—	24
36	Catechin	—	300
37	Vanillic Acid	—	300
38	Ouabain	—	300
39	Podophyllotoxin	—	14
40	Quinic Acid	—	218
41	Retinaldehyde	—	300
42	streptonigrin	—	299
43	Trifluridine	—	295
44	Niflumic Acid	—	300
45	Thyroxine	—	994
46	pterostilbene	—	299
47	Thyroxine	—	300
48	Masoprocol	—	300
49	Genistein	—	300
50	Kaempferols	—	300

About the Extracellular matrix organization Pathway

The Extracellular matrix organization pathway is catalogued in Reactome (ID: R-HSA-1474244) and involves 41 genes. In the BiohacksAI corpus, 92 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17, ADAMTS4, ADAMTS5, APP.