What compounds affect the Synthesis of PC pathway?

85 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of PC pathway (Reactome ID: R-HSA-1483191). These compounds target 6 genes within this pathway.

What genes are in the Synthesis of PC pathway?

The Synthesis of PC pathway involves 6 genes. Key genes include: ACHE, BCHE, CSNK2A1, CSNK2A2, CSNK2B, PHOSPHO1.

Synthesis of PC

REACTOME PATHWAY

Reactome: R-HSA-14831916 genes85 compounds

The Synthesis of PC pathway (Reactome ID: R-HSA-1483191) involves 6 genes and is affected by 85 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACHE BCHE CSNK2A1 CSNK2A2 CSNK2B PHOSPHO1

Compounds Affecting Synthesis of PC

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	fisetin	—	78
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Quercetin	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Kaempferols	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	chrysin	—	300
9	Vanillic Acid	—	300
10	ly294002	—	11
11	Physostigmine	—	300
12	Physostigmine	—	299
13	Berberine	—	300
14	ethopropazine	—	17
15	Disulfiram	—	297
16	Reserpine	—	297
17	bis(12)-hupyridone [Supplementary Concept]	—	300
18	Methylene Blue	—	200
19	Ranitidine	—	299
20	Chlorhexidine	—	299
21	Ethidium	—	300
22	Metergoline	—	144
23	Nicergoline	—	300
24	Progesterone	—	299
25	Hexachlorophene	—	300
26	Phenylglyoxal	—	300
27	Procainamide	—	297
28	Tilorone	—	300
29	Acetaldehyde	—	300
30	Carbaryl	—	300
31	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
32	Dihydroergotamine	—	299
33	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
34	Methysergide	—	300
35	Promethazine	—	121
36	Thioridazine	—	35
37	Caffeine	—	299
38	Amisulpride	—	298
39	Astemizole Antihistamine drug now withdrawn from	—	280
40	Hyoscyamine	—	296
41	Dinitrochlorobenzene	—	300
42	Edaravone	—	298
43	Methoxsalen	—	300
44	pirenperone	—	22
45	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
46	Vecuronium Bromide Monoquaternary homolog of PANCURONIUM.	—	298
47	caffeic acid	—	300
48	Fluoxetine	—	1,000
49	Rutin	—	300
50	Aripiprazole	—	298

About the Synthesis of PC Pathway

The Synthesis of PC pathway is catalogued in Reactome (ID: R-HSA-1483191) and involves 6 genes. In the BiohacksAI corpus, 85 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACHE, BCHE, CSNK2A1, CSNK2A2, CSNK2B.