What compounds affect the Metabolism of steroid hormones pathway?

130 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of steroid hormones pathway (Reactome ID: R-HSA-196071). These compounds target 9 genes within this pathway.

What genes are in the Metabolism of steroid hormones pathway?

The Metabolism of steroid hormones pathway involves 9 genes. Key genes include: CYP11B1, CYP11B2, CYP17A1, CYP19A1, HSD11B1, HSD17B1, HSD17B3, SERPINA6, STS.

Metabolism of steroid hormones

REACTOME PATHWAY

Reactome: R-HSA-1960719 genes130 compounds

The Metabolism of steroid hormones pathway (Reactome ID: R-HSA-196071) involves 9 genes and is affected by 130 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP11B1 CYP11B2 CYP17A1 CYP19A1 HSD11B1 HSD17B1 HSD17B3 SERPINA6 STS

Compounds Affecting Metabolism of steroid hormones

#	Compound	Targets Hit	Studies
1	Letrozole	—	298
2	Fadrozole	—	300
3	Androstenedione	—	300
4	Estrone	—	300
5	Kaempferols	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Clotrimazole	—	296
8	Testosterone	—	299
9	Miconazole	—	298
10	Dihydrotestosterone	—	300
11	stx64	—	2
12	Kaempferols	—	300
13	Masoprocol	—	300
14	Androsterone	—	300
15	Etiocholanolone	—	300
16	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
17	Anastrozole	—	298
18	chrysin	—	300
19	Methylene Blue	—	200
20	Bortezomib	—	300
21	cycloheximide	—	300
22	Ethidium	—	300
23	Fulvestrant	—	295
24	Lovastatin	—	300
25	Reserpine	—	297
26	Spironolactone	—	298
27	Vitamin	—	295
28	Dactinomycin	—	297
29	Disulfiram	—	297
30	Hexachlorophene	—	300
31	mg624	—	3
32	Ouabain	—	300
33	Rotenone	—	300
34	Acetaldehyde	—	300
35	Amoxapine	—	259
36	Astemizole Antihistamine drug now withdrawn from	—	280
37	Azacitidine	—	298
38	Azacitidine	—	300
39	Celecoxib	—	295
40	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
41	Chlorhexidine	—	299
42	Daunorubicin	—	298
43	Digoxin	—	299
44	Dinitrochlorobenzene	—	300
45	Emetine	—	298
46	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
47	Flutamide	—	298
48	Nisoldipine	—	297
49	Nitrofurantoin	—	297
50	ns398	—	116

About the Metabolism of steroid hormones Pathway

The Metabolism of steroid hormones pathway is catalogued in Reactome (ID: R-HSA-196071) and involves 9 genes. In the BiohacksAI corpus, 130 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP11B1, CYP11B2, CYP17A1, CYP19A1, HSD11B1.