Nuclear Events (kinase and transcription factor activation)

Q: What compounds affect the Nuclear Events (kinase and transcription factor activation) pathway?

88 compounds in the BiohacksAI corpus have documented interactions with genes in the Nuclear Events (kinase and transcription factor activation) pathway (Reactome ID: R-HSA-198725). These compounds target 20 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-19872520 genes88 compounds

The Nuclear Events (kinase and transcription factor activation) pathway (Reactome ID: R-HSA-198725) involves 20 genes and is affected by 88 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK5 CDK5R1 CREB1 DUSP3 EP300 F3 FOS ID4 MAPK1 MAPK11 MAPK14 MAPK3 MAPK7 MAPKAPK2 PPP2CA RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 SGK1

Compounds Affecting Nuclear Events (kinase and transcription factor activation)

#	Compound	Targets Hit	Studies
1	fisetin	—	78
2	sp600125	—	117
3	Sorafenib	—	300
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
7	withaferin	—	300
8	hydroxyfasudil [Supplementary Concept]	—	11
9	egcg	—	300
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	chrysin	—	300
12	Dasatinib	—	299
13	plumbagin [Supplementary Concept]	—	300
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	Afatinib	—	297
16	trequinsin hydrochloride	—	1
17	Quercetin	—	300
18	Masoprocol	—	300
19	pd98059	—	7
20	tyrphostin ag 1478	—	4
21	trametinib	—	296
22	indirubin	—	300
23	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
24	Anisomycin	—	247
25	Oleanolic Acid	—	300
26	cycloheximide	—	300
27	Disulfiram	—	297
28	Azacitidine	—	298
29	Azacitidine	—	300
30	Levalbuterol	—	1,000
31	Adenosine Monophosphate Adenine nucleotide containing	—	300
32	Levalbuterol	—	297
33	Bortezomib	—	300
34	Clofarabine	—	298
35	Dactinomycin	—	297
36	Danazol	—	298
37	Emetine	—	298
38	Ethidium	—	300
39	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
40	Sulbactam	—	299
41	Genistein	—	300
42	Testosterone	—	299
43	Ciclopirox	—	88
44	Cladribine	—	297
45	Clenbuterol	—	300
46	Corticosterone	—	300
47	Daunorubicin	—	298
48	Dinoprostone	—	296
49	Epinephrine	—	299
50	Ethinyl Estradiol	—	300

About the Nuclear Events (kinase and transcription factor activation) Pathway

The Nuclear Events (kinase and transcription factor activation) pathway is catalogued in Reactome (ID: R-HSA-198725) and involves 20 genes. In the BiohacksAI corpus, 88 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK5, CDK5R1, CREB1, DUSP3, EP300.