What compounds affect the Role of phospholipids in phagocytosis pathway?

205 compounds in the BiohacksAI corpus have documented interactions with genes in the Role of phospholipids in phagocytosis pathway (Reactome ID: R-HSA-2029485). These compounds target 5 genes within this pathway.

What genes are in the Role of phospholipids in phagocytosis pathway?

The Role of phospholipids in phagocytosis pathway involves 5 genes. Key genes include: PIK3CB, PIK3R1, PIK3R2, PLD2, SYK.

Role of phospholipids in phagocytosis

REACTOME PATHWAY

Reactome: R-HSA-20294855 genes205 compounds

The Role of phospholipids in phagocytosis pathway (Reactome ID: R-HSA-2029485) involves 5 genes and is affected by 205 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PIK3CB PIK3R1 PIK3R2 PLD2 SYK

Compounds Affecting Role of phospholipids in phagocytosis

#	Compound	Targets Hit	Studies
1	ly294002	—	11
2	pictilisib	—	25
3	alpelisib	—	227
4	Sirolimus	—	300
5	torin 1	—	10
6	Quercetin	—	300
7	Wortmannin	—	300
8	Dasatinib	—	299
9	Ouabain	—	300
10	Crizotinib	—	298
11	sp600125	—	117
12	Atorvastatin	—	1,000
13	Simvastatin	—	1,000
14	Methotrexate	—	289
15	Chlorhexidine	—	299
16	Clofarabine	—	298
17	Colchicine	—	300
18	cycloheximide	—	300
19	deguelin [Supplementary Concept]	—	151
20	Digoxin	—	299
21	Disulfiram	—	297
22	Emetine	—	298
23	Ezetimibe	—	296
24	Lovastatin	—	300
25	Medroxyprogesterone Acetate	—	299
26	Melphalan	—	300
27	Mometasone Furoate	—	292
28	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
29	Niclosamide	—	299
30	piceatannol	—	300
31	Podophyllotoxin	—	14
32	Thapsigargin	—	300
33	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
34	Trifluridine	—	295
35	tyrphostin ag 1478	—	4
36	fisetin	—	78
37	ag490	—	14
38	Axitinib	—	298
39	Azathioprine	—	300
40	Bortezomib	—	300
41	Maprotiline	—	299
42	Nocodazole Nocodazole is	—	215
43	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
44	Tripterygium	—	300
45	Vincristine	—	299
46	withaferin	—	300
47	Berberine	—	300
48	cbd	—	298
49	Doxycycline	—	999
50	Methylene Blue	—	200

About the Role of phospholipids in phagocytosis Pathway

The Role of phospholipids in phagocytosis pathway is catalogued in Reactome (ID: R-HSA-2029485) and involves 5 genes. In the BiohacksAI corpus, 205 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PIK3CB, PIK3R1, PIK3R2, PLD2, SYK.